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Details on Person UniProt:Q96C74 ROPN1L
| Class:Id | ReferenceGeneProduct:246336 |
|---|---|
| _chainChangeLog | chain:1-230 added on Sat February 7 2015 |
| _displayName | UniProt:Q96C74 ROPN1L |
| _timestamp | 2024-11-03 20:21:12 |
| chain | chain:1-230 |
| checksum | 5692E967769E8D45 |
| comment | FUNCTION Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia. Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.SUBUNIT Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (By similarity). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity). May interact with AKAP3 (PubMed:11278869). Interacts with CFAP61 (By similarity).INTERACTION Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.SIMILARITY Belongs to the ropporin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Ropporin-1-like protein shortName: ROPN1-like protein alternativeName: AKAP-associated sperm protein |
| geneName | ROPN1L ASP RSPH11 |
| identifier | Q96C74 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell projection Cilium Flagellum Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ROPN1L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995099] ENSEMBL:ENSG00000145491 ROPN1L [Homo sapiens] |
| secondaryIdentifier | ROP1L_HUMAN D3DTC9 Q9BZX0 |
| sequenceLength | 230 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9966868] ROPN1L [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969358] ROPN1L [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96C74 ROPN1L (246336)
