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Details on Person UniProt:Q9H4P4 RNF41
| Class:Id | ReferenceGeneProduct:246254 |
|---|---|
| _chainChangeLog | chain:1-317 added on Sat February 7 2015 |
| _displayName | UniProt:Q9H4P4 RNF41 |
| _timestamp | 2025-05-21 21:26:46 |
| chain | chain:1-317 |
| checksum | 46AE87AF8BE1A369 |
| comment | FUNCTION Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with USP8, ERBB3, PRKN and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1. Interacts with CLEC16A (By similarity).INTERACTION Detected in ovary, testis and prostate.PTM Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: E3 ubiquitin-protein ligase NRDP1 ecNumber: 2.3.2.27 alternativeName: RING finger protein 41 alternativeName: fullName evidence="14"RING-type E3 ubiquitin transferase NRDP1 |
| geneName | RNF41 FLRF NRDP1 SBBI03 |
| identifier | Q9H4P4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Autophagy Metal-binding Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | RNF41 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990373] ENSEMBL:ENSG00000181852 RNF41 [Homo sapiens] |
| secondaryIdentifier | RNF41_HUMAN A6NFW0 B2RBT8 O75598 |
| sequenceLength | 317 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969407] UniProt:Q9H4P4-1 RNF41 [Homo sapiens] [ReferenceIsoform:8969408] UniProt:Q9H4P4-2 RNF41 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:975977] RNF41 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9H4P4 RNF41 (246254)
