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Details on Person UniProt:Q8N6D2 RNF182
| Class:Id | ReferenceGeneProduct:246162 |
|---|---|
| _chainChangeLog | chain:1-247 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N6D2 RNF182 |
| _timestamp | 2024-11-03 20:07:24 |
| chain | chain:1-247 |
| checksum | 0012F055C7F2A233 |
| comment | FUNCTION E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with ATP6V0C.INTERACTION Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains (PubMed:18298843). Highly expressed in innate immune organs such as lymph nodes and spleen and in immune cells such as macrophages and dendritic cells (PubMed:31432514).DOMAIN The RING-type zinc finger domain is required for E3 ligase activity. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="7"E3 ubiquitin-protein ligase RNF182 ecNumber evidence="5"2.3.2.27 alternativeName: RING finger protein 182 alternativeName: fullName evidence="8"RING-type E3 ubiquitin transferase RNF182 |
| geneName | RNF182 |
| identifier | Q8N6D2 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Membrane Metal-binding Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RNF182 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991529] ENSEMBL:ENSG00000180537 RNF182 [Homo sapiens] |
| secondaryIdentifier | RN182_HUMAN B2RDG2 Q8NBG3 |
| sequenceLength | 247 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:976010] RNF182 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8N6D2 RNF182 (246162)
