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Details on Person UniProt:Q6P1L8 MRPL14
| Class:Id | ReferenceGeneProduct:245916 |
|---|---|
| _chainChangeLog | transit peptide:1-30 added on Fri February 6 2015;chain:31-145 added on Fri February 6 2015 |
| _displayName | UniProt:Q6P1L8 MRPL14 |
| _timestamp | 2024-11-03 19:48:17 |
| chain | transit peptide:1-30 chain:31-145 |
| checksum | 841360D2E84071A4 |
| comment | FUNCTION Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).SUBUNIT Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:35177605). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with MALSU1 (PubMed:22829778).SUBCELLULAR LOCATION Belongs to the universal ribosomal protein uL14 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="8"Large ribosomal subunit protein uL14m alternativeName: 39S ribosomal protein L14, mitochondrial shortName: L14mt shortName: MRP-L14 alternativeName: 39S ribosomal protein L32, mitochondrial shortName: L32mt shortName: MRP-L32 |
| geneName | MRPL14 MRPL32 RPML32 |
| identifier | Q6P1L8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Mitochondrion Proteomics identification Reference proteome Ribonucleoprotein Ribosomal protein Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MRPL14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989776] ENSEMBL:ENSG00000180992 MRPL14 [Homo sapiens] |
| secondaryIdentifier | RM14_HUMAN B2R575 Q96Q72 |
| sequenceLength | 145 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5368219] MRPL14 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q6P1L8 MRPL14 (245916)
