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Details on Person UniProt:Q7YR75 MRPL12
| Class:Id | ReferenceGeneProduct:245913 |
|---|---|
| _chainChangeLog | transit peptide:1-45 added on Sat February 7 2015;chain:46-198 added on Sat February 7 2015;transit peptide:1-45 for 245913 removed on Fri Feb 21 2025;chain:46-198 for 245913 removed on Fri Feb 21 2025;transit peptide:1-36 for 245913 added on Fri Feb 21 2025;chain:37-198 for 245913 added on Fri Feb 21 2025;chain:45-198 for 245913 added on Fri Feb 21 2025 |
| _displayName | UniProt:Q7YR75 MRPL12 |
| _timestamp | 2025-02-21 20:03:21 |
| chain | transit peptide:1-36 chain:37-198 chain:45-198 |
| checksum | 3A98308C159F3493 |
| comment | FUNCTION As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability.SUBUNIT Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with NOA1.SUBCELLULAR LOCATION Two mature forms are produced by differential two-step proteolytic cleavage. Cleaved by the mitochondrial processing protease to produce the long mature form and subsequently by the mitochondrial intermediate protease to produce the short mature form.PTM In the presence of CUL3, undergoes 'Lys-63'-linked ubiquitination at Lys-150 which results in proteasomal degradation.SIMILARITY Belongs to the bacterial ribosomal protein bL12 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="6"Large ribosomal subunit protein bL12m alternativeName: 39S ribosomal protein L12, mitochondrial shortName: L12mt shortName: MRP-L12 component recommendedName: fullName evidence="1"Large ribosomal subunit protein bL12m, long mature form /component component recommendedName: fullName evidence="1"Large ribosomal subunit protein bL12m, short mature form /component |
| geneName | MRPL12 |
| identifier | Q7YR75 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Isopeptide bond Mitochondrion Reference proteome Ribonucleoprotein Ribosomal protein Transit peptide Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MRPL12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RM12_BOVIN A5D9H8 |
| sequenceLength | 198 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:5432480] MRPL12 [mitochondrial inner membrane] [Bos taurus] |
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No pathways have been reviewed or authored by UniProt:Q7YR75 MRPL12 (245913)
