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Details on Person UniProt:Q7L0Q8 RHOU
| Class:Id | ReferenceGeneProduct:245634 |
|---|---|
| _chainChangeLog | chain:1-258 added on Sat February 7 2015 |
| _displayName | UniProt:Q7L0Q8 RHOU |
| _timestamp | 2025-08-15 21:40:57 |
| chain | chain:1-258 |
| checksum | D90059DE82288B97 |
| comment | FUNCTION Binds to and activates protein kinase PAK1 (PubMed:11459829). Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration (PubMed:11459829, PubMed:17620058, PubMed:18086875, PubMed:21834987). Also stimulates quiescent cells to reenter the cell cycle (PubMed:11459829). Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound (PubMed:16472646).COFACTOR Interacts with PAK1 (PubMed:26598620). Interacts with PAK3 (PubMed:17620058). Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation, interacts with ARHGAP31 (PubMed:21565175). Interacts with PTK2B/PYK2 (PubMed:18086875). Interacts with PAK4; the interaction is PAK4 kinase activity-independent and protects RHOU from ubiquitination (PubMed:26598620).INTERACTION Localizes to podosomes in SRC-transformed cells.ALTERNATIVE PRODUCTS Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.PTM Ubiquitinated. 'Lys-48'-linked ubiquitination at Lys-177 and Lys-248 by the ECS(RAB40A) complex leading to its degradation.PTM Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation.SIMILARITY Belongs to the small GTPase superfamily. Rho family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Rho-related GTP-binding protein RhoU alternativeName: CDC42-like GTPase 1 alternativeName: GTP-binding protein-like 1 alternativeName: Rho GTPase-like protein ARHU alternativeName: Ryu GTPase alternativeName: Wnt-1 responsive Cdc42 homolog 1 shortName evidence="17"WRCH-1 |
| geneName | RHOU ARHU CDC42L1 G28K WRCH1 SB128 |
| identifier | Q7L0Q8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell junction Cell membrane Cell projection Golgi apparatus GTP-binding Isopeptide bond Lipoprotein Magnesium Membrane Metal-binding Nucleotide-binding Palmitate Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RHOU |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8948453] ENSEMBL:ENSG00000116574 RHOU [Homo sapiens] |
| secondaryIdentifier | RHOU_HUMAN B1AKN1 Q59FE9 Q8TDQ2 |
| sequenceLength | 258 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:245635] UniProt:Q7L0Q8-2 RHOU [Homo sapiens] [ReferenceIsoform:409239] UniProt:Q7L0Q8-1 RHOU [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:194901] RHOU [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:194914] RHOU [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9726857] p-Y254-RHOU [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9726860] p-Y254-RHOU [endosome membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9726854] O4'-phospho-L-tyrosine at 254 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q7L0Q8 RHOU (245634)
