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Details on Person UniProt:E1BMF7 USP13
| Class:Id | ReferenceGeneProduct:2455463 |
|---|---|
| _chainChangeLog | chain:1-863 added on Sat February 7 2015 |
| _displayName | UniProt:E1BMF7 USP13 |
| _timestamp | 2023-11-03 16:17:00 |
| chain | chain:1-863 |
| checksum | 04357616964550B5 |
| comment | FUNCTION Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy, endoplasmic reticulum-associated degradation (ERAD), cell cycle progression or DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Alternatively, forms with NEDD4 a deubiquitination complex, which subsequently stabilizes VPS34 to promote autophagy. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Regulates the cell cycle progression by stabilizing cell cycle proteins such as SKP2 and AURKB. In addition, plays an important role in maintaining genomic stability and in DNA replication checkpoint activation via regulation of RAP80 and TOPBP1. Deubiquitinates the multifunctional protein HMGB1 and subsequently drives its nucleocytoplasmic localization and its secretion. Positively regulates type I and type II interferon signalings by deubiquitinating STAT1 but negatively regulates antiviral response by deubiquitinating STING1.CATALYTIC ACTIVITY Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ACTIVITY REGULATION Specifically inhibited by spautin-1 (specific and potent autophagy inhibitor-1), a derivative of MBCQ that binds to USP13 and inhibits deubiquitinase activity. Regulated by PIK3C3/VPS34-containing complexes. The weak deubiquitinase activity in vitro suggests the existence of some mechanism that activates the enzyme (By similarity).SUBUNIT Interacts with UFD1. Interacts (via UBA domains) with SIAH2 (when ubiquitinated). Interacts with BAG6; the interaction is direct and may mediate UBL4A deubiquitination. Interacts (via UBA 2 domain) with AMFR; the interaction is direct. Interacts with UBL4A; may be indirect via BAG6. Interacts with NEDD4.SUBCELLULAR LOCATION The UBP-type zinc finger has lost its ability to bind ubiquitin and USP13 is not activated by unanchored ubiquitin.DOMAIN The UBA domains mediate binding to ubiquitin.SIMILARITY Belongs to the peptidase C19 family. |
| created | [InstanceEdit:2455454] Weiser, JD |
| description | recommendedName: Ubiquitin carboxyl-terminal hydrolase 13 ecNumber: 3.4.19.12 alternativeName: Deubiquitinating enzyme 13 alternativeName: Ubiquitin thioesterase 13 alternativeName: Ubiquitin-specific-processing protease 13 |
| geneName | USP13 |
| identifier | E1BMF7 |
| isSequenceChanged | FALSE |
| keyword | Autophagy Cytoplasm Hydrolase Isopeptide bond Metal-binding Phosphoprotein Protease Reference proteome Repeat Thiol protease Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | USP13 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | UBP13_BOVIN |
| sequenceLength | 863 |
| species | [Species:48898] Bos taurus |
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No pathways have been reviewed or authored by UniProt:E1BMF7 USP13 (2455463)
