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Details on Person UniProt:E9Q1P8 Irf2bp2
| Class:Id | ReferenceGeneProduct:2455462 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-570 added on Fri February 6 2015;initiator methionine:1 for 2455462 removed on Fri Nov 03 2023;initiator methionine: for 2455462 added on Fri Nov 03 2023;initiator methionine: for 2455462 removed on Fri Aug 15 2025;initiator methionine:1 for 2455462 added on Fri Aug 15 2025 |
| _displayName | UniProt:E9Q1P8 Irf2bp2 |
| _timestamp | 2025-08-15 21:15:35 |
| chain | initiator methionine:1 chain:2-570 |
| checksum | 533BE0AC9CE6A527 |
| comment | FUNCTION Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation (By similarity).SUBUNIT Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4 (By similarity).SUBCELLULAR LOCATION The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2.PTM Phosphorylation at Ser-343 is required for nuclear targeting.SIMILARITY Belongs to the IRF2BP family. |
| created | [InstanceEdit:2455454] Weiser, JD |
| description | recommendedName: Interferon regulatory factor 2-binding protein 2 shortName: IRF-2-binding protein 2 shortName: IRF-2BP2 |
| geneName | Irf2bp2 |
| identifier | E9Q1P8 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Activator Cytoplasm Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Irf2bp2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | I2BP2_MOUSE Q8BJC6 |
| sequenceLength | 570 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:E9Q1P8 Irf2bp2 (2455462)
