Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:E9Q3T6 Prdm14
| Class:Id | ReferenceGeneProduct:2455455 |
|---|---|
| _chainChangeLog | chain:1-561 added on Sat February 7 2015 |
| _displayName | UniProt:E9Q3T6 Prdm14 |
| _timestamp | 2023-11-03 18:33:02 |
| chain | chain:1-561 |
| checksum | 03D83B5365C9FBAB |
| comment | FUNCTION Transcription factor that has both positive and negative roles on transcription (By similarity). Plays a role in cellular pluripotency. Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation.SUBUNIT Interacts with CBFA2T2.SUBCELLULAR LOCATION Restricted to embryonic stem cells and primordial germ cells. Not detected in epiblast-derived stem cells.DEVELOPMENTAL STAGE At 3.5 dpc, weak and transient expression in the inner cell mass cells of blastocysts. This expression disappears by 5.5 dpc. Expression starts again in committed PGCs around 6.5 dpc in the extraembryonic mesoderm contiguous from the most proximal epiblast (at protein level). Expression persists specifically in PGCs until about 13.5-14.5 dpc both in females and males.DISRUPTION PHENOTYPE Mutant mice are born with an expected Mendelian ratio and looked grossly normal. However, both females and males are sterile, ovaries and testes being completely devoid of germ cells.SIMILARITY Belongs to the class V-like SAM-binding methyltransferase superfamily. |
| created | [InstanceEdit:2455454] Weiser, JD |
| description | recommendedName: PR domain zinc finger protein 14 ecNumber: 2.1.1.- alternativeName: PR domain-containing protein 14 |
| geneName | Prdm14 |
| identifier | E9Q3T6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure DNA-binding Metal-binding Methyltransferase Nucleus Reference proteome Repeat S-adenosyl-L-methionine Transcription Transcription regulation Transferase Zinc Zinc-finger |
| modified | [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Prdm14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PRD14_MOUSE Q3URU1 |
| sequenceLength | 561 |
| species | [Species:48892] Mus musculus |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:E9Q3T6 Prdm14 (2455455)
