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Details on Person UniProt:Q8N1W1 ARHGEF28
| Class:Id | ReferenceGeneProduct:245462 |
|---|---|
| _chainChangeLog | chain:1-1705 added on Fri February 6 2015 |
| _displayName | UniProt:Q8N1W1 ARHGEF28 |
| _timestamp | 2025-05-21 21:22:53 |
| chain | chain:1-1705 |
| checksum | D4DD6331BD259CC7 |
| comment | FUNCTION Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).SUBUNIT Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA.INTERACTION Colocalizes with the microtubule radial and cortical systems.ALTERNATIVE PRODUCTS Phosphorylated on tyrosine upon stimulation of cells by laminin.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Rho guanine nucleotide exchange factor 28 alternativeName: 190 kDa guanine nucleotide exchange factor shortName: p190-RhoGEF shortName: p190RhoGEF alternativeName: Rho guanine nucleotide exchange factor |
| geneName | ARHGEF28 KIAA1998 RGNEF |
| identifier | Q8N1W1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Coiled coil Cytoplasm Differentiation Guanine-nucleotide releasing factor Membrane Metal-binding Phosphoprotein Proteomics identification Reference proteome RNA-binding Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | ARHGEF28 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994056] ENSEMBL:ENSG00000214944 ARHGEF28 [Homo sapiens] |
| secondaryIdentifier | ARG28_HUMAN B2RXG7 B4E3K4 B5MDA3 B7ZW32 E9PC75 Q8NCM7 Q96E37 Q9H6L3 Q9H6W0 |
| sequenceLength | 1705 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:245463] UniProt:Q8N1W1-2 ARHGEF28 [Homo sapiens] [ReferenceIsoform:245464] UniProt:Q8N1W1-3 ARHGEF28 [Homo sapiens] [ReferenceIsoform:245465] UniProt:Q8N1W1-4 ARHGEF28 [Homo sapiens] [ReferenceIsoform:411197] UniProt:Q8N1W1-1 ARHGEF28 [Homo sapiens] [ReferenceIsoform:8969552] UniProt:Q8N1W1-5 ARHGEF28 [Homo sapiens] [ReferenceIsoform:8969553] UniProt:Q8N1W1-6 ARHGEF28 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3928474] ARHGEF28 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8N1W1 ARHGEF28 (245462)
