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Details on Person RPE65 isomero-hydrolyses atREs to 11cROL

Class:Id	Reaction:2453833
_displayName	RPE65 isomero-hydrolyses atREs to 11cROL
_doRelease	TRUE
_timestamp	2026-02-18 21:20:56
authored	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
catalystActivity	[CatalystActivity:2453844] all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity of RPE65 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:13977] lipid droplet [Compartment:876] plasma membrane
created	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
edited	[InstanceEdit:2453822] Jassal, Bijay, 2012-08-17
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:9982476] atRE [lipid droplet]
internalReviewed	[InstanceEdit:9982705] D'Eustachio, Peter, 2026-02-18
isChimeric	FALSE
literatureReference	[LiteratureReference:2453806] Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65 [LiteratureReference:2454082] The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
modified	[InstanceEdit:2454089] Jassal, Bijay, 2012-08-20 [InstanceEdit:2454115] Jassal, Bijay, 2012-08-21 [InstanceEdit:2454263] Jassal, Bijay, 2012-08-22 [InstanceEdit:2465977] Jassal, Bijay, 2012-09-05 [InstanceEdit:2468357] Jassal, Bijay, 2012-09-17 [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2470325] Jassal, Bijay, 2012-09-18 [InstanceEdit:2473461] Jassal, Bijay, 2012-09-24 [InstanceEdit:2534412] Jassal, Bijay, 2012-10-26 [InstanceEdit:2550421] Jassal, Bijay, 2012-11-02 [InstanceEdit:2586575] Jassal, Bijay, 2012-11-15 [InstanceEdit:2864105] Jassal, Bijay, 2012-12-19 [InstanceEdit:3006583] Jassal, Bijay, 2013-01-31 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9982703] D'Eustachio, Peter, 2026-02-18 [InstanceEdit:9982704] D'Eustachio, Peter, 2026-02-18 [InstanceEdit:9982753] D'Eustachio, Peter, 2026-02-18
name	RPE65 isomero-hydrolyses atREs to 11cROL Retinoid isomerohydrolase isomero-hydrolyses retinyl esters to 11-cis-retinol
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:30927] 11cROL [cytosol] [SimpleEntity:9982478] RCOO- [lipid droplet]
precedingEvent	[Reaction:2453855] LRAT esterifies RBP1:atROL and FACYLs to atREs [Homo sapiens] [Reaction:74843] atROL binds RBP1 to form RBP1:atROL [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[PositiveRegulation:2454123] Positive regulation by 'MYO7A [cytosol]'
regulationReference	[RegulationReference:9642038] Positive regulation by 'MYO7A [cytosol]' The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65
releaseDate	2013-03-12
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9982754] D'Eustachio, Peter, 2026-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200471] R-HSA-2453833.5
structureModified	[InstanceEdit:9982703] D'Eustachio, Peter, 2026-02-18
summation	[Summation:2453897] All-trans-retinol esters (atREs) serve as substrates for ret...
(hasEvent)	[Pathway:2453902] The canonical retinoid cycle in rods (twilight vision) [Homo sapiens]
(precedingEvent)	[Reaction:2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984653] Update Tracker - [Reaction:2453833] RPE65 isomero-hydrolyses atREs to 11cROL - v96:[add_removeInput, add_removeOutput]
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