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Details on Person In the bloodstream, circulating retinol binding protein 4 (R...
| Class:Id | Summation:2453700 |
|---|---|
| _displayName | In the bloodstream, circulating retinol binding protein 4 (R... |
| _timestamp | 2012-08-17 13:28:44 |
| created | [InstanceEdit:2453711] Jassal, B, 2012-08-14 |
| modified | [InstanceEdit:2453717] Jassal, B, 2012-08-14 [InstanceEdit:2453822] Jassal, Bijay, 2012-08-17 |
| text | In the bloodstream, circulating retinol binding protein 4 (RBP4, in complex with atROL), binds transthyretin (TTR, a 51 kDa protein) in a 1:1 molar complex (Naylor & Newcomer, 1999). The resultant TTR:RBP4:atROL complex is larger and therefore less susceptible to glomerular filtration, maintaining normal levels of retinoid and RBP4 in the circulation. In TTR-deficient mice, plasma levels of atROL and RBP4 were observed to be 5% of wild type levels, highlighting the importance of TTR binding to RBP4:atROL (Episkopou et al. 1993). TTR is also a transporter for thyroxine in the brain (not shown here) (Herbert et al. 1986). |
| (summation) | [Reaction:2404134] RBP4:atROL binds TTR [Homo sapiens] |
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