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Details on Person UniProt:P28749-2 RBL1
| Class:Id | ReferenceIsoform:244887 |
|---|---|
| _chainChangeLog | chain:1-1068 added on Sat February 7 2015 |
| _displayName | UniProt:P28749-2 RBL1 |
| _timestamp | 2024-11-03 19:53:34 |
| chain | chain:1-1068 |
| checksum | 2BC4876EA04BDB31 |
| comment | FUNCTION Key regulator of entry into cell division (PubMed:17671431). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation (By similarity). Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression (By similarity). Controls histone H4 'Lys-20' trimethylation (By similarity). Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters (By similarity). Potent inhibitor of E2F-mediated trans-activation (PubMed:8319904). May act as a tumor suppressor (PubMed:8319904).SUBUNIT Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2 (PubMed:16360038, PubMed:17671431). The complex exists in quiescent cells where it represses cell cycle-dependent genes (PubMed:17671431). It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2 (PubMed:17671431). Interacts with AATF (PubMed:12450794). Interacts with KDM5A (PubMed:7935440). Interacts with KMT5B and KMT5C (By similarity). Interacts with USP4 (By similarity). Interacts with RBBP9 (By similarity).SUBUNIT (Microbial infection) Interacts with SV40 and JC virus large T antigens. Large T antigen, but not E1A, binds only to the unphosphorylated form.SUBUNIT (Microbial infection) Interacts with JC virus small t antigen.INTERACTION Cell-cycle arrest properties are inactivated by phosphorylation on Thr-332, Ser-640, Ser-964 and Ser-975 by CDK4.SIMILARITY Belongs to the retinoblastoma protein (RB) family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Retinoblastoma-like protein 1 alternativeName: 107 kDa retinoblastoma-associated protein shortName: p107 alternativeName: pRb1 |
| geneName | RBL1 |
| identifier | P28749 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Chromatin regulator Direct protein sequencing Host-virus interaction Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Tumor suppressor |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RBL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8964488] ENSEMBL:ENSG00000080839 RBL1 [Homo sapiens] |
| secondaryIdentifier | RBL1_HUMAN A8K2W5 Q4VXA0 Q8N5K6 Q9H1L5 Q9H1M1 |
| sequenceLength | 1068 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P28749-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P28749-2 RBL1 (244887)
