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Details on Person UniProt:O60671 RAD1

Class:Id	ReferenceGeneProduct:244680
_chainChangeLog	chain:1-282 added on Fri February 6 2015
_displayName	UniProt:O60671 RAD1
_timestamp	2024-11-03 20:20:59
chain	chain:1-282
checksum	075FBD4CF8A4FDB2
comment	FUNCTION Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603).SUBUNIT Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1 (PubMed:10846170, PubMed:10884395, PubMed:31776186). The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2 (PubMed:10846170, PubMed:10884395, PubMed:15314187, PubMed:15556996, PubMed:15871698, PubMed:15897895, PubMed:16216273). The 9-1-1 complex associates with the RAD17-RFC complex (PubMed:12578958). RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A and RAD9B (PubMed:10359610, PubMed:10777662, PubMed:11944979, PubMed:14500360, PubMed:14611806, PubMed:15314187, PubMed:15556996, PubMed:16216273). Interacts with DNAJC7 (PubMed:11573955). Interacts with RHNO1; interaction is direct (PubMed:31776186).INTERACTION Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the rad1 family.CAUTION Was reported to possess 3'->5' double stranded DNA exonuclease activity (PubMed:9660799). However, this activity was not confirmed by other publications (PubMed:9716408).SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Cell cycle checkpoint protein RAD1 shortName: hRAD1 alternativeName: Rad1-like DNA damage checkpoint protein
geneName	RAD1 REC1
identifier	O60671
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing DNA damage DNA repair Nucleus Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	RAD1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000270] ENSEMBL:ENSG00000113456 RAD1 [Homo sapiens]
secondaryIdentifier	RAD1_HUMAN O75572 O95304 Q1W161 Q5KSM0 Q5KSM1 Q9UEP1
sequenceLength	282
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:244681] UniProt:O60671-2 RAD1 [Homo sapiens] [ReferenceIsoform:244682] UniProt:O60671-3 RAD1 [Homo sapiens] [ReferenceIsoform:401716] UniProt:O60671-1 RAD1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:176382] RAD1 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O60671 RAD1 (244680)