Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O00391 QSOX1
| Class:Id | ReferenceGeneProduct:244553 |
|---|---|
| _chainChangeLog | signal peptide:1-29 added on Sat February 7 2015;chain:30-747 added on Sat February 7 2015 |
| _displayName | UniProt:O00391 QSOX1 |
| _timestamp | 2025-02-21 19:21:50 |
| chain | signal peptide:1-29 chain:30-747 |
| checksum | 52639D09A50E00C5 |
| comment | FUNCTION Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560).CATALYTIC ACTIVITY 2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2COFACTOR Binds 1 FAD per subunit.SUBUNIT Monomer.SUBCELLULAR LOCATION A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.SUBCELLULAR LOCATION Found in the extracellular medium of quiescent cells but is not found in proliferating cells.ALTERNATIVE PRODUCTS Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.INDUCTION Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.PTM N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379).MISCELLANEOUS 'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts.SIMILARITY Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Sulfhydryl oxidase 1 shortName: hQSOX ecNumber evidence="10 13 14 15 17 18 19"1.8.3.2 alternativeName: fullName evidence="23 28"Quiescin Q6 |
| geneName | QSOX1 QSCN6 UNQ2520/PRO6013 |
| identifier | O00391 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disulfide bond FAD Flavoprotein Glycoprotein Golgi apparatus Membrane Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | QSOX1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004913] ENSEMBL:ENSG00000116260 QSOX1 [Homo sapiens] |
| secondaryIdentifier | QSOX1_HUMAN Q59G29 Q5T2X0 Q8TDL6 Q8WVP4 |
| sequenceLength | 747 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:244554] UniProt:O00391-2 QSOX1 [Homo sapiens] [ReferenceIsoform:401110] UniProt:O00391-1 QSOX1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6799714] QSOX1 [specific granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:6800466] QSOX1 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6800984] QSOX1 [tertiary granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:8848890] QSOX1 [platelet alpha granule lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956765] QSOX1 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956895] p-QSOX1 [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8956970] phosphorylated residue at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00391 QSOX1 (244553)
