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Details on Person UniProt:Q5TB80 CEP162
| Class:Id | ReferenceGeneProduct:244516 |
|---|---|
| _chainChangeLog | chain:1-1403 added on Sat February 7 2015 |
| _displayName | UniProt:Q5TB80 CEP162 |
| _timestamp | 2024-11-03 20:04:42 |
| chain | chain:1-1403 |
| checksum | 93638BE4BC3A4B29 |
| comment | FUNCTION Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.SUBUNIT Interacts with CEP290 (PubMed:23644468). Interacts with CPNE4 (By similarity). Interacts with alpha-tubulin (By similarity).INTERACTION Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis.ALTERNATIVE PRODUCTS Promotes ectopic assembly of transition zone components at cilia tips when targeted outside distal ends of centrioles, generating extra-long cilia with strikingly swollen tips.SIMILARITY Belongs to the CEP162 family.CAUTION Was initially thought to regulate chromosome segregation and mitotic spindle assembly (PubMed:16302001). However, it was later shown that its absence neither affect mitosis nor centriole duplication (PubMed:23644468).SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Centrosomal protein of 162 kDa shortName: Cep162 alternativeName: Protein QN1 homolog |
| geneName | CEP162 C6orf84 KIAA1009 QN1 |
| identifier | Q5TB80 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Microtubule Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CEP162 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991762] ENSEMBL:ENSG00000135315 CEP162 [Homo sapiens] |
| secondaryIdentifier | CE162_HUMAN A6PVL7 A6PVL8 Q6P475 Q9Y2L2 |
| sequenceLength | 1403 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:244517] UniProt:Q5TB80-2 CEP162 [Homo sapiens] [ReferenceIsoform:407398] UniProt:Q5TB80-1 CEP162 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5626646] CEP162 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q5TB80 CEP162 (244516)
