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Details on Person UniProt:Q9NRF8 CTPS2
| Class:Id | ReferenceGeneProduct:244462 |
|---|---|
| _chainChangeLog | chain:1-586 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NRF8 CTPS2 |
| _timestamp | 2026-02-20 22:37:10 |
| chain | chain:1-586 |
| checksum | AC1CF2E67D89741B |
| comment | FUNCTION CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen (PubMed:10899599, PubMed:16179339, PubMed:31873303, PubMed:34583994). Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (PubMed:10899599, PubMed:16179339).CATALYTIC ACTIVITY UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)ACTIVITY REGULATION Strongly inhibited by CTP.PATHWAY Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.SUBUNIT Homotetramer (PubMed:31873303). Polymerizes into filaments of stacked tetramers through conserved intertetramer interactions (PubMed:31873303). Filaments dynamically switch between substrate- (active) and product-bound (inactive) conformations with unique architectures (PubMed:31873303).INTERACTION Cytoplasmic and nuclear; detected in long filamentous structures named cytoophidium.SIMILARITY Belongs to the CTP synthase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: CTP synthase 2 ecNumber evidence="4 6"6.3.4.2 alternativeName: CTP synthetase 2 alternativeName: UTP--ammonia ligase 2 |
| geneName | CTPS2 |
| identifier | Q9NRF8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cytoplasm Glutamine amidotransferase Ligase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Pyrimidine biosynthesis Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CTPS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989164] ENSEMBL:ENSG00000047230 CTPS2 [Homo sapiens] |
| secondaryIdentifier | PYRG2_HUMAN B3KWM2 Q9BRI0 Q9H809 Q9H8K9 |
| sequenceLength | 586 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:504053] CTPS2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NRF8 CTPS2 (244462)
