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Details on Person UniProt:Q6NZI2 CAVIN1
| Class:Id | ReferenceGeneProduct:244339 |
|---|---|
| _chainChangeLog | chain:1-390 added on Sat February 7 2015 |
| _displayName | UniProt:Q6NZI2 CAVIN1 |
| _timestamp | 2025-08-15 22:18:17 |
| chain | chain:1-390 |
| checksum | E37945A9C9E819D4 |
| comment | FUNCTION Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues (PubMed:18056712, PubMed:18191225, PubMed:19726876). Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template (By similarity) (PubMed:18056712, PubMed:18191225, PubMed:19726876). The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A (By similarity).SUBUNIT Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4. Homotrimer (By similarity). Interacts with TTF1 (PubMed:9582279). Interacts with RNA polymerase I subunit POLR1A/RPA1. Binds the 3' end of pre-rRNA. Interacts with transcription factor ZNF148 (By similarity). Interacts with LIPE in the adipocyte cytoplasm (PubMed:17026959). Interacts with CAV1 and CAVIN3 (By similarity). Interacts with CAVIN2 (PubMed:19525939, PubMed:24567387). Interacts with CAVIN4 and CAV3 (PubMed:24567387).INTERACTION Translocates to the cytoplasm from the caveolae upon insulin stimulation (PubMed:17026959). Colocalizes with CAV1 in lipid rafts in adipocytes. Localizes in the caveolae in a caveolin-dependent manner (By similarity).ALTERNATIVE PRODUCTS The leucine-zipper domain 1 is essential for its localization in the caveolae.PTM Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity. Phosphorylation at Tyr-156 is essential for its functionin the regulation of ribosomal transcriptional activity.PTM Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent.PTM Monoubiquitinated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CAVIN family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="22"Caveolae-associated protein 1 alternativeName: Cavin-1 alternativeName: Polymerase I and transcript release factor |
| geneName | CAVIN1 PTRF FKSG13 |
| identifier | Q6NZI2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell membrane Coiled coil Congenital generalized lipodystrophy Cytoplasm Diabetes mellitus Direct protein sequencing Endoplasmic reticulum Isopeptide bond Membrane Microsome Mitochondrion Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding rRNA-binding Transcription Transcription regulation Transcription termination Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CAVIN1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996207] ENSEMBL:ENSG00000177469 CAVIN1 [Homo sapiens] |
| secondaryIdentifier | CAVN1_HUMAN B2RAW7 O00535 Q6GMY1 Q96H74 Q9BT85 Q9HAP4 |
| sequenceLength | 390 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:244340] UniProt:Q6NZI2-2 CAVIN1 [Homo sapiens] [ReferenceIsoform:244341] UniProt:Q6NZI2-3 CAVIN1 [Homo sapiens] [ReferenceIsoform:408375] UniProt:Q6NZI2-1 CAVIN1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:74981] PTRF [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9714278] CAVIN1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q6NZI2 CAVIN1 (244339)
