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Details on Person UniProt:P0C6B2-2 Ptcra
| Class:Id | ReferenceIsoform:244221 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Fri February 6 2015;chain:17-199 added on Fri February 6 2015 |
| _displayName | UniProt:P0C6B2-2 Ptcra |
| _timestamp | 2025-02-21 18:40:53 |
| chain | signal peptide:1-16 chain:17-199 |
| checksum | 5141E9361BF494BA |
| comment | FUNCTION Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that plays a crucial role in early T-cell development, particularly alpha-beta T cell differentiation (PubMed:9647201, PubMed:7596413). Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex.SUBUNIT Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1 (By similarity).SUBCELLULAR LOCATION Isoform 1 is expressed at higher levels than isoform 2 in the thymus while only isoform 2 is expressed in polyclonal beta-only cells. Isoform 1 shows a predominant expression in immature thymocytes. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="9"Pre T-cell antigen receptor alpha shortName evidence="9"pT-alpha shortName evidence="9"pTa alternativeName: gp33 alternativeName: pT-alpha-TCR |
| geneName | Ptcra |
| identifier | P0C6B2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Disulfide bond Glycoprotein Membrane Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Ptcra |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PTCRA_MOUSE |
| sequenceLength | 199 |
| species | [Species:48892] Mus musculus |
| variantIdentifier | P0C6B2-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P0C6B2-2 Ptcra (244221)
