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Details on Person UniProt:Q6ISU1-3 PTCRA
| Class:Id | ReferenceIsoform:244219 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-281 added on Fri February 6 2015 |
| _displayName | UniProt:Q6ISU1-3 PTCRA |
| _timestamp | 2026-02-20 22:25:51 |
| chain | signal peptide:1-23 chain:24-281 |
| checksum | A49B86A151619B9F |
| comment | FUNCTION Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that has a crucial role in early T-cell development, particularly alpha-beta T cell differentiation.SUBUNIT Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1 (PubMed:22795130).SUBCELLULAR LOCATION Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.DEVELOPMENTAL STAGE Expressed in fetal life in CD34+ progenitors present in the liver at 18 weeks of gestation but is absent in CD34+ precursors from fetal bone marrow at any developmental stage up to 22 weeks.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="14"Pre T-cell antigen receptor alpha shortName evidence="9 10"pT-alpha shortName: pTa alternativeName: pT-alpha-TCR |
| geneName | PTCRA |
| identifier | Q6ISU1 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Membrane Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | PTCRA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992077] ENSEMBL:ENSG00000171611 PTCRA [Homo sapiens] |
| secondaryIdentifier | PTCRA_HUMAN Q5TFZ7 |
| sequenceLength | 281 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q6ISU1-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6ISU1-3 PTCRA (244219)
