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Details on Person UniProt:Q969U7 PSMG2
| Class:Id | ReferenceGeneProduct:244160 |
|---|---|
| _chainChangeLog | chain:1-264 added on Sat February 7 2015 |
| _displayName | UniProt:Q969U7 PSMG2 |
| _timestamp | 2024-11-03 20:20:55 |
| chain | chain:1-264 |
| checksum | 7D138B81C3C20EF9 |
| comment | FUNCTION Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.SUBUNIT Forms a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.INTERACTION Widely expressed with highest levels in lung, brain and colon. Moderately expressed in muscle, stomach, spleen and heart. Weakly expressed in small intestine, pancreas and liver. Highly expressed in hepatocellular carcinomas with low levels in surrounding liver tissue.PTM Degraded by the proteasome upon completion of 20S proteasome maturation.DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PSMG2 family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Proteasome assembly chaperone 2 shortName: PAC-2 alternativeName: Hepatocellular carcinoma-susceptibility protein 3 alternativeName: Tumor necrosis factor superfamily member 5-induced protein 1 |
| geneName | PSMG2 HCCA3 PAC2 TNFSF5IP1 |
| identifier | Q969U7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Chaperone Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PSMG2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998540] ENSEMBL:ENSG00000128789 PSMG2 [Homo sapiens] |
| secondaryIdentifier | PSMG2_HUMAN B0YJB3 Q6IAH4 Q9NRV1 V9GYH7 |
| sequenceLength | 264 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967994] UniProt:Q969U7-1 PSMG2 [Homo sapiens] [ReferenceIsoform:8967995] UniProt:Q969U7-2 PSMG2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9908053] PSMG2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q969U7 PSMG2 (244160)
