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Details on Person UniProt:Q2KJ25 PSMD12
| Class:Id | ReferenceGeneProduct:244103 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-456 added on Fri February 6 2015;initiator methionine:1 for 244103 removed on Fri Nov 03 2023;initiator methionine: for 244103 added on Fri Nov 03 2023;initiator methionine: for 244103 removed on Fri Aug 15 2025;initiator methionine:1 for 244103 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q2KJ25 PSMD12 |
| _timestamp | 2025-08-15 21:33:07 |
| chain | initiator methionine:1 chain:2-456 |
| checksum | C6144FBC24F304F0 |
| comment | FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.SUBUNIT Component of the 19S proteasome regulatory particle complex (By similarity). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (By similarity). The regulatory particle is made of a lid composed of 9 subunits including PSMD12, a base containing 6 ATPases and few additional components (By similarity). Interacts with ERCC6 (By similarity).SIMILARITY Belongs to the proteasome subunit p55 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: 26S proteasome non-ATPase regulatory subunit 12 alternativeName: 26S proteasome regulatory subunit RPN5 |
| geneName | PSMD12 |
| identifier | Q2KJ25 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Isopeptide bond Proteasome Reference proteome Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PSMD12 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PSD12_BOVIN |
| sequenceLength | 456 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:9918607] bPSMD12 [cytosol] [Bos taurus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q2KJ25 PSMD12 (244103)
