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Details on Person UniProt:Q9BZG2 ACP4
| Class:Id | ReferenceGeneProduct:243576 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-426 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BZG2 ACP4 |
| _timestamp | 2024-11-03 19:38:16 |
| chain | signal peptide:1-26 chain:27-426 |
| checksum | BE930398041DB061 |
| comment | FUNCTION May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125).CATALYTIC ACTIVITY a phosphate monoester + H2O = an alcohol + phosphateSUBUNIT Homodimer.SUBCELLULAR LOCATION Expressed mainly in the testis. Also expressed in the brain where they are enriched at the postsynaptic sites. Expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas and skeletal muscle. Expression is significantly lower in testicular cancer tissues than in normal testicular tissues. Isoform 3 is expressed in the testis, trachea, prostate and bone marrow.INDUCTION Up-regulated by mibolerone (a synthetic androgen) and dihydrotestosterone (DHT) and is down-regulated by estrogen and progestin.PTM Glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the histidine acid phosphatase family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="7"Testicular acid phosphatase ecNumber: 3.1.3.2 alternativeName: fullName evidence="9"Acid phosphatase 4 |
| geneName | ACP4 ACPT |
| identifier | Q9BZG2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Amelogenesis imperfecta Disease variant Disulfide bond Glycoprotein Hydrolase Membrane Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ACP4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997927] ENSEMBL:ENSG00000142513 ACP4 [Homo sapiens] |
| secondaryIdentifier | PPAT_HUMAN C0H3P7 Q9BZG3 Q9BZG4 |
| sequenceLength | 426 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:243577] UniProt:Q9BZG2-2 ACP4 [Homo sapiens] [ReferenceIsoform:243578] UniProt:Q9BZG2-3 ACP4 [Homo sapiens] [ReferenceIsoform:413568] UniProt:Q9BZG2-1 ACP4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:3229239] ACPT [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BZG2 ACP4 (243576)
