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Details on Person UniProt:Q9NY27 PPP4R2
| Class:Id | ReferenceGeneProduct:243558 |
|---|---|
| _chainChangeLog | chain:1-417 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NY27 PPP4R2 |
| _timestamp | 2024-11-03 19:42:48 |
| chain | chain:1-417 |
| checksum | 75298CD34A202F40 |
| comment | FUNCTION Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.SUBUNIT Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A and PPP4C-PPP4R2-PPP4R3B. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with DDX20/GEMIN3 and GEMIN4. Interacts with RPA2; this DNA damage-dependent interaction recruits PPP4C leading to RPA2 dephosphorylation.INTERACTION Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.ALTERNATIVE PRODUCTS Widely expressed.SIMILARITY Belongs to the PPP4R2 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Serine/threonine-protein phosphatase 4 regulatory subunit 2 |
| geneName | PPP4R2 SBBI57 |
| identifier | Q9NY27 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm Cytoskeleton mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PPP4R2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993239] ENSEMBL:ENSG00000163605 PPP4R2 [Homo sapiens] |
| secondaryIdentifier | PP4R2_HUMAN A8K1I6 Q2TAJ9 Q498B8 Q8WXX6 |
| sequenceLength | 417 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:243559] UniProt:Q9NY27-2 PPP4R2 [Homo sapiens] [ReferenceIsoform:243560] UniProt:Q9NY27-3 PPP4R2 [Homo sapiens] [ReferenceIsoform:414898] UniProt:Q9NY27-1 PPP4R2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5687747] PPP4R2 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NY27 PPP4R2 (243558)
