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Details on Person UniProt:Q9Y244 POMP
| Class:Id | ReferenceGeneProduct:243496 |
|---|---|
| _chainChangeLog | chain:1-141 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y244 POMP |
| _timestamp | 2026-02-20 23:09:43 |
| chain | chain:1-141 |
| checksum | 2136624D232EF1C7 |
| comment | FUNCTION Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.SUBUNIT Constituent of preproteasomes, but not of mature 20S proteasomes. Within the preproteasome, may directly interact with PSMB1/beta6, PSMB4/beta7, PSMB5/beta5, PSMB6/beta1 and PSMB9/beta1i. Interaction with PSMB8/beta5i has been observed in PubMed:10973495, but not in PubMed:10926487. Forms tetramers.SUBCELLULAR LOCATION Strongly expressed from the basal layer to the granular layer of healthy epidermis, whereas in KLICK patients there is a gradual decrease of expression toward the granular layer.INDUCTION By IFNG/IFN-gamma.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the POMP/UMP1 family.CAUTION Although this protein has been named voltage-gated K channel beta subunit 4.1 in Ref.1 and Ref.2, there is no evidence that it may play a role in ion transport. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="10"Proteasome maturation protein alternativeName: Proteassemblin alternativeName: fullName evidence="9"Protein UMP1 homolog shortName evidence="9"hUMP1 alternativeName: Voltage-gated K channel beta subunit 4.1 |
| geneName | POMP C13orf12 UMP1 HSPC014 HSPC036 PNAS-110 |
| identifier | Q9Y244 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Chaperone Cytoplasm Direct protein sequencing Endoplasmic reticulum Ichthyosis Isopeptide bond Membrane Microsome Nucleus Palmoplantar keratoderma Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | POMP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004901] ENSEMBL:ENSG00000132963 POMP [Homo sapiens] |
| secondaryIdentifier | POMP_HUMAN A5HKJ2 D6MXU3 Q9HB69 |
| sequenceLength | 141 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9908067] POMP [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y244 POMP (243496)
