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Details on Person UniProt:Q5XG87 TENT4A
| Class:Id | ReferenceGeneProduct:243449 |
|---|---|
| _chainChangeLog | chain:1-772 added on Fri February 6 2015;chain:1-772 for 243449 removed on Fri May 5 2023;chain:1-792 for 243449 added on Fri May 5 2023 |
| _displayName | UniProt:Q5XG87 TENT4A |
| _timestamp | 2025-02-21 19:51:56 |
| chain | chain:1-792 |
| checksum | 49F6A74943B7A620 |
| comment | FUNCTION Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078).CATALYTIC ACTIVITY RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphateCOFACTOR Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of a helicase (MTREX), an oligadenylate polymerase (TENT4B or TENT4A), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes.INTERACTION Excluded from nucleolus, weak staining detected in the cytoplasm.ALTERNATIVE PRODUCTS Exhibits poor nucleotidyl transferase activity.SIMILARITY Belongs to the DNA polymerase type-B-like family.CAUTION Was originally thought to have DNA polymerase activity. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="13"Terminal nucleotidyltransferase 4A alternativeName: DNA polymerase sigma alternativeName: LAK-1 alternativeName: fullName evidence="13"Non-canonical poly(A) RNA polymerase PAPD7 ecNumber evidence="2"2.7.7.19 alternativeName: PAP-associated domain-containing protein 7 alternativeName: TRAMP-like complex polyadenylate polymerase alternativeName: fullName evidence="13"Terminal guanylyltransferase ecNumber evidence="6"2.7.7.- alternativeName: Terminal uridylyltransferase 5 shortName: TUTase 5 alternativeName: Topoisomerase-related function protein 4-1 shortName: TRF4-1 |
| geneName | TENT4A PAPD7 POLS TRF4 |
| identifier | Q5XG87 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Cytoplasm Magnesium Manganese Metal-binding mRNA processing Nucleotide-binding Nucleotidyltransferase Nucleus Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TENT4A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958132] ENSEMBL:ENSG00000112941 TENT4A [Homo sapiens] |
| secondaryIdentifier | PAPD7_HUMAN A0A0X1KG68 A8K1E2 M1JCE6 O43289 Q17RZ1 Q9Y6C1 |
| sequenceLength | 792 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969326] UniProt:Q5XG87-1 TENT4A [Homo sapiens] [ReferenceIsoform:8969327] UniProt:Q5XG87-2 TENT4A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6802430] PAPD7(1-653)-RAF1(331-648) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6802541] PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8958035] PAPD7 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9933561] TENT4A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9935840] TENT4A [nucleolus] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q5XG87 TENT4A (243449)
