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Details on Person UniProt:Q9UIW2 PLXNA1
| Class:Id | ReferenceGeneProduct:243281 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-1896 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UIW2 PLXNA1 |
| _timestamp | 2024-11-03 19:38:13 |
| chain | signal peptide:1-26 chain:27-1896 |
| checksum | 76E5C9C0710C7FC1 |
| comment | FUNCTION Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis.SUBUNIT Interacts directly with NRP1 and NRP2. Interacts with PLXN1B. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4. Interacts (via TIG domains) with TREM2; the interaction mediates SEMA6D binding and signaling through TYROBP.SUBCELLULAR LOCATION Detected in fetal brain, lung, liver and kidney.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the plexin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Plexin-A1 alternativeName: Semaphorin receptor NOV |
| geneName | PLXNA1 NOV PLXN1 |
| identifier | Q9UIW2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Coiled coil Disease variant Disulfide bond Glycoprotein Intellectual disability Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PLXNA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003152] ENSEMBL:ENSG00000114554 PLXNA1 [Homo sapiens] |
| secondaryIdentifier | PLXA1_HUMAN |
| sequenceLength | 1896 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:396932] PLXNA1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:419614] p-Y-PLXNA1 [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:419611] O4'-phospho-L-tyrosine at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UIW2 PLXNA1 (243281)
