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Details on Person NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs

Class:Id	Reaction:2429643
_displayName	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs
_doRelease	TRUE
_timestamp	2026-02-18 21:20:55
authored	[InstanceEdit:2429684] Jassal, B, 2012-08-09
catalystActivity	[CatalystActivity:2470273] all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity of NREH [early endosome]
compartment	[Compartment:17941] early endosome [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2429684] Jassal, B, 2012-08-09
crossReference	[DatabaseIdentifier:9982477] RHEA:38556
edited	[InstanceEdit:2429684] Jassal, B, 2012-08-09
input	[Complex:2429682] CR:atREs:HSPG:apoE [early endosome] [Homo sapiens] [SimpleEntity:2429665] H2O [early endosome]
internalReviewed	[InstanceEdit:9982705] D'Eustachio, Peter, 2026-02-18
isChimeric	FALSE
literatureReference	[LiteratureReference:2470274] Hydrolysis of retinyl palmitate by enzymes of rat pancreas and liver. Differentiation of bile salt-dependent and bile salt-independent, neutral retinyl ester hydrolases in rat liver [LiteratureReference:2470278] Neutral and acid retinyl ester hydrolases associated with rat liver microsomes: relationships to microsomal cholesteryl ester hydrolases [LiteratureReference:2470271] Retinyl esters are hydrolyzed in early endosomes of J774 macrophages
modified	[InstanceEdit:2453645] Jassal, B, 2012-08-13 [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2473461] Jassal, Bijay, 2012-09-24 [InstanceEdit:2473613] Jassal, Bijay, 2012-09-24 [InstanceEdit:2550421] Jassal, Bijay, 2012-11-02 [InstanceEdit:2586575] Jassal, Bijay, 2012-11-15 [InstanceEdit:2859060] Jassal, B, 2012-12-19 [InstanceEdit:3006583] Jassal, Bijay, 2013-01-31 [InstanceEdit:3006617] Jassal, B, 2013-01-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9982628] D'Eustachio, Peter, 2026-02-18 [InstanceEdit:9982704] D'Eustachio, Peter, 2026-02-18 [InstanceEdit:9982753] D'Eustachio, Peter, 2026-02-18
name	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs an all-trans-retinyl ester + H2O => all-trans-retinol + a fatty acid + H(+) Retinyl esters (complexed with HSPG:apoE) are hydrolysed to retinol in hepatocytes
output	[SimpleEntity:2429673] H+ [early endosome] [SimpleEntity:2473610] atROL [cytosol] [Complex:2429649] CR [early endosome] [Homo sapiens] [EntityWithAccessionedSequence:2429687] APOE [early endosome] [Homo sapiens] [DefinedSet:2076618] HSPGs [plasma membrane] [Homo sapiens] [SimpleEntity:9982627] RCOO- [early endosome]
precedingEvent	[Reaction:2404131] LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol [Homo sapiens] [Reaction:2423785] CR:atREs binds apoE and HSPG [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2013-03-12
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31 [InstanceEdit:9982754] D'Eustachio, Peter, 2026-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200335] R-HSA-2429643.3
structureModified	[InstanceEdit:9982628] D'Eustachio, Peter, 2026-02-18
summation	[Summation:9982626] Once inside liver parenchymal cells, all-trans-retinyl ester...
(hasEvent)	[Pathway:975634] Retinoid metabolism and transport [Homo sapiens]
(precedingEvent)	[Reaction:2855259] atROL binds RBP1 (parenchymal cell) [Homo sapiens] [Reaction:8956427] RETSAT reduces atROL to at-13,14-dhROL [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984687] Update Tracker - [Reaction:2429643] NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs - v96:[add_removeOutput, add_removeSummation]
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