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Details on Person Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly

Class:IdLiteratureReference:2428864
_displayNameTwo human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
_timestamp2012-08-08 19:29:30
author[Person:2428868] George, Julie
[Person:2428867] Motshwene, Precious G
[Person:2428875] Wang, Hui
[Person:2428869] Kubarenko, Andriy V
[Person:2428865] Rautanen, Anna
[Person:2428876] Mills, Tara C
[Person:2428872] Hill, Adrian V S
[Person:165841] Gay, Nicholas J
[Person:2428871] Weber, Alexander N R
created[InstanceEdit:2428877] Shamovsky, V, 2012-08-08
journalJ. Biol. Chem.
pages1341-53
pubMedIdentifier20966070
titleTwo human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
volume286
year2011
(literatureReference)[Reaction:937079] MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 [Homo sapiens]
[Reaction:975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 [Homo sapiens]
[FailedReaction:5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 [Homo sapiens]
[FailedReaction:5602383] Defective MyD88 does not oligomerize within the activated TLR2/4 complex [Homo sapiens]
[FailedReaction:5602393] Defective MyD88 does not oligomerize within the activated TLR7/8 complex [Homo sapiens]
[FailedReaction:5602413] Defective MyD88 does not form complex with IRAK4 in IL1R signaling [Homo sapiens]
[Summation:5607803] All TLRs, except for TLR3, employ the MyD88-dependent signal...
[Summation:5607900] Myeloid differentiation primary response (MyD88) is an adapt...
[Summation:5607906] Myeloid differentiation primary response (MyD88) is an adapt...
[Summation:5607919] Myeloid differentiation primary response (MyD88) is an adapt...
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