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Details on Person Laminin is a large trimeric glycoprotein, found in all basem...
| Class:Id | Summation:2426671 |
|---|---|
| _displayName | Laminin is a large trimeric glycoprotein, found in all basem... |
| _timestamp | 2013-07-29 14:51:36 |
| created | [InstanceEdit:2426629] Jupe, S, 2012-08-08 |
| literatureReference | [LiteratureReference:2426653] Structure and biological activity of basement membrane proteins [LiteratureReference:2426642] Structure and function of laminin: anatomy of a multidomain glycoprotein [LiteratureReference:2426646] The laminin family [LiteratureReference:2426615] Form and function: the laminin family of heterotrimers [LiteratureReference:2426346] Laminin forms an independent network in basement membranes [LiteratureReference:2328150] Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity [LiteratureReference:2426643] Molecular analysis of laminin N-terminal domains mediating self-interactions [LiteratureReference:3900295] Laminin network formation studied by reconstitution of ternary nodes in solution |
| modified | [InstanceEdit:2867920] Jupe, S, 2012-12-19 [InstanceEdit:4084534] Jupe, S, 2013-07-29 |
| text | Laminin is a large trimeric glycoprotein, found in all basement membranes and the extracellular matrix of the developing central nervous system (Timpl 1989, Beck et al. 1990, Tryggvason 1993, Colognato & Yurchenco 2000). It forms extended polymeric networks that contact the cell surface. Laminin can self-assemble even in the absence of other basement membrane components (Yurchenco et al. 1992) suggesting a key developmental role. Laminin polymerization is thought to be driven by attachment of laminin to cell surface receptors, dystroglycan or integrins, and possibly other receptors. Receptor-engaged laminin exceeds the critical concentration for self-assembly (Colognato & Yurchenco 2000). Binding experiments agree with a proposed three-arm interaction model where the short arm laminin amino-terminal (LN) domains interact alpha-beta, alpha-gamma and beta-gamma to form a polygonal network (Yurchenco et al. 1985, Odenthal et al. 2004). |
| (summation) | [Polymerisation:2426626] Formation of laminin networks [Mus musculus] |
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