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Details on Person The IG3 repeat in domain IV of perlecan is the principal sit...

Class:IdSummation:2426535
_displayNameThe IG3 repeat in domain IV of perlecan is the principal sit...
_timestamp2012-12-19 17:28:33
created[InstanceEdit:2426542] Jupe, S, 2012-08-03
literatureReference[LiteratureReference:2426543] Structural and genetic analysis of laminin-nidogen interaction
[LiteratureReference:2328191] Recombinant domain IV of perlecan binds to nidogens, laminin-nidogen complex, fibronectin, fibulin-2 and heparin
[LiteratureReference:2426482] Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan
[LiteratureReference:2426537] Structural basis for the high-affinity interaction of nidogen-1 with immunoglobulin-like domain 3 of perlecan
[LiteratureReference:2327728] Basement-membrane heparan sulfate proteoglycan binds to laminin by its heparan sulfate chains and to nidogen by sites in the protein core
[LiteratureReference:2327818] Mapping of nidogen binding sites for collagen type IV, heparan sulfate proteoglycan, and zinc
[LiteratureReference:2327907] Nidogen-2: a new basement membrane protein with diverse binding properties
modified[InstanceEdit:2426629] Jupe, S, 2012-08-08
[InstanceEdit:2867920] Jupe, S, 2012-12-19
textThe IG3 repeat in domain IV of perlecan is the principal site of interaction with nidogen-1, binding to the G2 domain. Nidogen-1 in turn binds to the laminin gamma1-subunit (Mayer et al. 1998), providing a bridge between the two proteins (Hopf et al. 1999, 2001, Kvansakul et al. 2001). Perlecan also binds to nidogen-2 (Battaglia et al. 1992, Reinhardt et al. 1993, Kohfeldt et al. 1998).
(summation)[Reaction:2426528] Laminins:Nidogens binds HSPG2 [Mus musculus]
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