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Details on Person Cartilage oligomeric matrix protein (COMP, thrombospondin-5)...

Class:IdSummation:2426318
_displayNameCartilage oligomeric matrix protein (COMP, thrombospondin-5)...
_timestamp2012-12-19 17:24:50
created[InstanceEdit:2426268] Jupe, S, 2012-07-31
literatureReference[LiteratureReference:2426258] Distribution of cartilage molecules in the developing mouse joint
[LiteratureReference:2426329] Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage
[LiteratureReference:2426316] Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure
[LiteratureReference:2426326] Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins
[LiteratureReference:2426286] Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein
[LiteratureReference:2426250] Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
textCartilage oligomeric matrix protein (COMP, thrombospondin-5) is a 524-kDa pentameric glycoprotein expressed primarily in cartilage, tendon, ligament and synovium. In adult cartilage, COMP has been shown to be located primarily in the inter-territorial matrix between chondrocytes (Murphy et al. 1999). The mature protein is pentameric with each monomer linked to its neighbour by a disulphide bond, located at the amino terminus of the protein (Hedbom et al. 1992, Morgelin et al. 1992).

COMP binds integrin alpha5beta1 (Chen et al. 2005), integrin alphaVbeta3 (Neidhart et al.2005) and CD47 (also known as integrin-associated peptide or IAP, Rock et al. 2010) on the cell surface of chondrocytes and fibroblasts.
(summation)[Reaction:2426259] COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [Homo sapiens]
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