Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Activation of gene expression by SREBF (SREBP)

Class:IdPathwayDiagram:2426207
_displayNameDiagram of Activation of gene expression by SREBF (SREBP)
_timestamp2026-04-22 22:07:17
created[InstanceEdit:2426208] May, B, 2012-07-30
height1066
modified[InstanceEdit:2426241] May, B, 2012-07-31
[InstanceEdit:2426449] May, B, 2012-08-03
[InstanceEdit:2426556] May, B, 2012-08-04
[InstanceEdit:2426596] May, B, 2012-08-08
[InstanceEdit:5260272] May, B, 2014-02-07
[InstanceEdit:5260273] May, B, 2014-02-07
[InstanceEdit:6800054] May, Bruce, 2015-09-27
[InstanceEdit:8934515] May, Bruce, 2016-08-09
[InstanceEdit:8963807] May, Bruce, 2017-02-13
[InstanceEdit:9036880] May, Bruce, 2018-02-11
[InstanceEdit:9608308] May, Bruce, 2018-05-12
[InstanceEdit:9629286] May, Bruce, 2018-11-20
[InstanceEdit:9961220] D'Eustachio, Peter, 2025-07-21
[InstanceEdit:9987236] D'Eustachio, Peter, 2026-04-10
[InstanceEdit:9987322] D'Eustachio, Peter, 2026-04-13
[InstanceEdit:9987661] D'Eustachio, Peter, 2026-04-22
representedPathway[Pathway:2426168] Activation of gene expression by SREBF (SREBP) [Homo sapiens]
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lineColor="255 153 102" insets="32 36 2787 666"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="5" /> <Component id="6" /> <Component id="7" /> <Component id="8" /> <Component id="9" /> <Component id="10" /> <Component id="11" /> <Component id="12" /> <Component id="13" /> <Component id="14" /> <Component id="15" /> <Component id="17" /> <Component id="18" /> <Component id="19" /> <Component id="20" /> <Component id="21" /> <Component id="22" /> <Component id="23" /> <Component id="26" /> <Component id="27" /> <Component id="29" /> <Component id="30" /> <Component id="31" /> <Component id="32" /> <Component id="33" /> <Component id="35" /> <Component id="36" /> <Component id="37" /> <Component id="40" /> <Component id="41" /> <Component id="42" /> <Component id="43" /> <Component id="44" /> <Component id="45" /> <Component id="46" /> <Component id="49" /> <Component id="50" /> <Component id="51" /> <Component id="52" /> <Component id="53" 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bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NF-Y</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="14" reactomeId="1655744" position="825 61" bounds="747 49 156 24" textPosition="760 51" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="15" reactomeId="2393984" position="1196 264" bounds="1163 239 66 51" textPosition="1167 266"> <Properties> <displayName>TM7SF2 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="16" reactomeId="1655714" position="1298 433" bounds="1251 407 94 53" textPosition="1255 410" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:NF-Y:TM7SF2 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="18" reactomeId="2393968" position="348 279" bounds="312 254 72 51" textPosition="325 281"> <Properties> <displayName>GPAM gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="19" reactomeId="2426131" position="400 460" bounds="361 435 78 51" textPosition="363 436" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C:NF-Y:GPAM gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="21" reactomeId="2393979" position="571 346" bounds="544 321 54 51" textPosition="550 348"> <Properties> <displayName>FASN gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableProtein id="22" reactomeId="1592223" position="521 82" bounds="496 71 50 23" textPosition="506 71"> <Properties> <displayName>SP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="23" reactomeId="1655738" position="682 508" bounds="638 484 88 49" textPosition="640 483" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C:NF-Y:SP1:FASN gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="27" reactomeId="2393996" position="969 399" bounds="938 374 62 51" textPosition="941 401"> <Properties> <displayName>ELOVL6 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="28" reactomeId="1655762" position="1064 540" bounds="1011 519 107 42" textPosition="1017 525" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:ELOVL6 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="30" reactomeId="2393989" position="835 377" bounds="804 352 62 51" textPosition="815 379"> <Properties> <displayName>FDPS gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="31" reactomeId="2426134" position="942 587" bounds="888 567 109 41" textPosition="892 572" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:NF-Y:FDPS gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="33" reactomeId="2393972" position="1083 336" bounds="1050 311 67 51" textPosition="1052 338"> <Properties> <displayName>HMGCS1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="34" reactomeId="2426129" position="1180 444" bounds="1131 419 98 50" textPosition="1132 419" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:NF-Y:HMGCS1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="36" reactomeId="2393991" position="699 406" bounds="665 381 69 51" textPosition="675 408"> <Properties> <displayName>FDFT1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="37" reactomeId="2426135" position="793 548" bounds="745 523 97 50" textPosition="746 523" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:NF-Y:SP1:FDFT1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="41" reactomeId="2393967" position="1439 200" bounds="1418 175 43 51" textPosition="1421 202"> <Properties> <displayName>LSS gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="42" reactomeId="2065551" position="1664 60" bounds="1591 48 147 24" textPosition="1610 50" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="43" reactomeId="2426137" position="1529 377" bounds="1483 359 93 37" textPosition="1481 360" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:LSS gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="45" reactomeId="2393981" position="1555 218" bounds="1529 193 53 51" textPosition="1536 220"> <Properties> <displayName>MVD gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="46" reactomeId="2426130" position="1647 378" bounds="1602 360 91 37" textPosition="1610 361" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:MVD gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="50" reactomeId="2393990" position="1827 263" bounds="1799 238 56 51" textPosition="1799 265"> <Properties> <displayName>HMGCR gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="51" reactomeId="2426128" position="1937 378" bounds="1883 358 109 40" textPosition="1883 362" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:HMGCR gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="53" reactomeId="2394001" position="1984 244" bounds="1958 219 52 51" textPosition="1959 246"> <Properties> <displayName>SC5DL gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="54" reactomeId="2426140" position="2081 381" bounds="2028 362 107 38" textPosition="2033 364" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SC5DL gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="55" reactomeId="381204" position="2151 60" bounds="2126 49 50 22" textPosition="2132 49" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="58" reactomeId="2426132" position="2537 434" bounds="2487 407 101 55" textPosition="2487 412" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SP1:CYP51A1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="61" reactomeId="1592223" position="2000 60" bounds="1971 48 59 25" textPosition="1986 49" /> <org.gk.render.RenderableGene id="63" reactomeId="2393971" position="1673 250" bounds="1642 225 63 51" textPosition="1646 252"> <Properties> <displayName>DHCR7 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="64" reactomeId="2426124" position="1785 397" bounds="1738 371 95 53" textPosition="1744 374" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SP1:DHCR7 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="66" reactomeId="2393998" position="2682 206" bounds="2655 181 54 51" textPosition="2656 208"> <Properties> <displayName>GGPS1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="67" reactomeId="2426126" position="2771 400" bounds="2731 374 80 52" textPosition="2731 376" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SP1:GGPS1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="69" reactomeId="2393982" position="2587 268" bounds="2566 243 43 51" textPosition="2569 270"> <Properties> <displayName>IDI1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="70" reactomeId="2426138" position="2668 400" bounds="2625 373 86 55" textPosition="2630 378" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SP1:IDI1 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="72" reactomeId="2393995" position="2279 266" bounds="2255 241 49 51" textPosition="2260 268"> <Properties> <displayName>MVK gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="73" reactomeId="2426127" position="2369 440" bounds="2328 415 82 50" textPosition="2331 415" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SP1:MVK gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="77" reactomeId="2393994" position="2123 251" bounds="2099 226 48 51" textPosition="2100 253"> <Properties> <displayName>PMVK gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="78" reactomeId="2426139" position="2223 381" bounds="2179 357 88 49" textPosition="2185 356" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:NF-Y:SP1:PMVK gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="80" reactomeId="2393973" position="1317 198" bounds="1287 173 60 51" textPosition="1297 200"> <Properties> <displayName>SQLE gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="81" reactomeId="2426136" position="1417 380" bounds="1373 361 88 39" textPosition="1379 364" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2:SQLE gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="83" reactomeId="191308" position="1864 915" bounds="1830 904 68 22" textPosition="1830 904"> <Properties> <displayName>HMGCR-1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="84" reactomeId="400154" position="1964 621" bounds="1915 596 98 50" textPosition="1921 596" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableCompartment id="85" reactomeId="12045" position="1411 919" bounds="312 849 2199 141" textPosition="318 954" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>endoplasmic reticulum membrane</displayName> </Properties> <Components> <Component id="83" /> <Component id="87" /> <Component id="99" /> <Component id="116" /> <Component id="120" /> <Component id="122" /> <Component id="128" /> <Component id="132" /> <Component id="134" /> <Component id="142" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="87" reactomeId="196423" position="1756 914" bounds="1726 903 60 22" textPosition="1731 903"> <Properties> <displayName>DHCR7</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="89" reactomeId="1660609" position="78 810" bounds="45 797 66 26" textPosition="54 799"> <Properties> <displayName>ACACA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="91" reactomeId="52493" position="194 813" bounds="161 800 66 26" textPosition="170 802"> <Properties> <displayName>ACACB</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="93" reactomeId="191317" position="1612 793" bounds="1582 780 61 27" textPosition="1595 782"> <Properties> <displayName>MVD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="97" reactomeId="981566" position="889 812" bounds="852 799 74 27" textPosition="871 801"> <Properties> <displayName>FDPS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="99" reactomeId="191369" position="729 922" bounds="693 910 72 25" textPosition="706 911"> <Properties> <displayName>FDFT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="100" reactomeId="400154" position="809 663" bounds="765 638 88 50" textPosition="766 638" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PPARA:RXRA Coactivator complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="104" reactomeId="199233" position="654 806" bounds="609 794 91 25" textPosition="636 795"> <Properties> <displayName>FASN</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="106" reactomeId="191415" position="2726 919" bounds="2693 903 66 32" textPosition="2702 908"> <Properties> <displayName>GGPS1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="108" reactomeId="61855" position="238 909" bounds="190 895 97 28" textPosition="194 898"> <Properties> <displayName>GPAM(1-828)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="109" reactomeId="17906" position="172 928" bounds="43 876 258 104" textPosition="46 943" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>mitochondrial outer membrane</displayName> </Properties> <Components> <Component id="108" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="111" reactomeId="191329" position="1127 807" bounds="1090 796 75 22" textPosition="1098 796"> <Properties> <displayName>HMGCS1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="112" reactomeId="400154" position="1200 640" bounds="1160 608 81 64" textPosition="1162 608" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableProtein id="114" reactomeId="191358" position="2605 947" bounds="2572 935 67 24" textPosition="2590 936"> <Properties> <displayName>IDI1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="116" reactomeId="194721" position="2464 948" bounds="2427 935 75 27" textPosition="2433 937"> <Properties> <displayName>CYP51A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="120" reactomeId="191371" position="1494 916" bounds="1468 903 53 26" textPosition="1481 905"> <Properties> <displayName>LSS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="122" reactomeId="195662" position="2023 916" bounds="1990 904 67 24" textPosition="2004 905"> <Properties> <displayName>SC5D</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="124" reactomeId="191375" position="2329 805" bounds="2297 790 64 30" textPosition="2312 794"> <Properties> <displayName>MVK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="126" reactomeId="191348" position="2187 808" bounds="2153 792 68 32" textPosition="2166 797"> <Properties> <displayName>PMVK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="128" reactomeId="191395" position="1374 915" bounds="1345 902 59 27" textPosition="1356 904"> <Properties> <displayName>SQLE</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="132" reactomeId="194710" position="1256 917" bounds="1220 904 73 27" textPosition="1229 906"> <Properties> <displayName>TM7SF2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="134" reactomeId="548680" position="1004 919" bounds="970 907 68 24" textPosition="978 908"> <Properties> <displayName>ELOVL6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="135" reactomeId="5660440" position="1960 560" bounds="1913 534 94 53" textPosition="1918 537" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>MTF1 dimer:12Zn2+:HMGCR gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableGene id="139" reactomeId="6800051" position="461 383" bounds="434 358 55 51" textPosition="443 385"> <Properties> <displayName>SCD gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="140" reactomeId="1655743" position="545 489" bounds="500 470 90 38" textPosition="503 472" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C:SCD gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="142" reactomeId="400117" position="482 922" bounds="454 909 57 27" textPosition="467 911"> <Properties> <displayName>SCD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableGene id="143" reactomeId="5660427" position="2437 264" bounds="2406 239 62 51" textPosition="2404 266"> <Properties> <displayName>CYP51A1 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="153" reactomeId="9987253" position="319 231" bounds="284 208 71 46" textPosition="288 204" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SP1,SREBP1A,1C</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="167" reactomeId="9987250" position="462 322" bounds="425 305 74 35" textPosition="430 304" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,NF-Y</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="174" reactomeId="9987227" position="677 351" bounds="642 328 71 47" textPosition="646 325" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,NF-Y,SP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="185" reactomeId="2065537" position="574 424" bounds="540 408 68 32" textPosition="542 404" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="204" reactomeId="9987228" position="1965 305" bounds="1932 288 66 35" textPosition="1933 287" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2,SP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="208" reactomeId="9987228" position="2111 312" bounds="2078 295 66 35" textPosition="2079 294" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="209" reactomeId="1655728" position="1314 290" bounds="1276 271 77 39" textPosition="1280 274" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2:NF-Y</displayName> </Properties> <Shortcuts> <Shortcut id="209" /> <Shortcut id="262" /> <Shortcut id="264" /> </Shortcuts> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="216" reactomeId="9987254" position="2572 333" bounds="2541 310 63 47" textPosition="2541 307" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="226" reactomeId="9987254" position="1821 326" bounds="1790 303 63 47" textPosition="1790 300" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2,NF-Y,SP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="233" reactomeId="9987315" position="1433 292" bounds="1401 275 64 34" textPosition="1401 273" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,2,NF-Y</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="260" reactomeId="9987323" position="834 456" bounds="801 433 66 47" textPosition="802 430" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SREBP1A,1C,2,NF-Y,SP1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="262" reactomeId="1655728" position="1195 363" bounds="1160 344 70 38" textPosition="1160 346" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="264" reactomeId="1655728" position="956 463" bounds="922 444 69 38" textPosition="922 446" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="5" reactomeId="2426160" points="149 132, 145 234, 158 336" position="145 234" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="252 79" /> <Input id="7" points="132 103" /> </Inputs> <Outputs> <Output id="8" /> </Outputs> <Catalysts> <Catalyst id="6" points="260 79, 167 157" /> </Catalysts> <Properties> <displayName>SREBP1A,1C binds the ACACA promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9" reactomeId="2426153" points="273 185, 272 291, 275 403" position="272 291" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="10" points="259 158" /> <Input id="22" points="493 92" /> <Input id="6" points="274 79" /> </Inputs> <Outputs> <Output id="11" /> </Outputs> <Catalysts> <Catalyst id="153" points="300 257" /> </Catalysts> <Properties> <displayName>SREBP1A,1C binds the ACACB promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="2065966" points="1249 224, 1250 288, 1289 404" position="1250 288" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13" points="653 79" /> <Input id="14" points="856 76" /> <Input id="15" points="1238 241" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Catalysts> <Catalyst id="209" points="1273 288" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds the TM7SF2 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="2426158" points="413 265, 394 346, 398 432" position="394 346" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13" points="609 88" /> <Input id="6" points="283 79" /> <Input id="18" points="393 256" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Catalysts> <Catalyst id="167" points="422 335" /> </Catalysts> <Properties> <displayName>SREBP1A,1C binds the GPAM promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="2426148" points="631 324, 636 411, 670 481" position="636 411" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="6" points="292 79" /> <Input id="13" points="623 88" /> <Input id="21" points="607 323" /> <Input id="22" points="526 97" /> </Inputs> <Outputs> <Output id="23" /> </Outputs> <Catalysts> <Catalyst id="174" points="660 378" /> </Catalysts> <Properties> <displayName>SREBP1A,1C binds the FASN promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="26" reactomeId="2426149" points="1027 371, 1026 434, 1056 516" position="1026 434" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="27" points="1009 376" /> <Input id="14" points="832 76" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> <Catalysts> <Catalyst id="14" points="833 76, 1054 383, 1054 434" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds the ELOVL6 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="2426147" points="904 370, 894 462, 934 564" position="894 462" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="30" points="875 354" /> <Input id="13" points="634 88" /> <Input id="14" points="828 76" /> </Inputs> <Outputs> <Output id="31" /> </Outputs> <Catalysts> <Catalyst id="264" points="919 462" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds the FDPS promoter</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="32" reactomeId="2426150" points="1142 310, 1135 364, 1165 416" position="1135 364" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13" points="649 88" /> <Input id="14" points="840 76" /> <Input id="33" points="1126 313" /> </Inputs> <Outputs> <Output id="34" /> </Outputs> <Catalysts> <Catalyst id="262" points="1157 363" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds the HMGCS1 promoter</displayName> <isChanged>true</isChanged> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="2426146" points="768 401, 769 456, 786 520" position="769 456" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="36" points="743 383" /> <Input id="13" points="628 88" /> <Input id="22" points="530 97, 715 320" /> <Input id="14" points="822 76" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> <Catalysts> <Catalyst id="260" points="798 456" /> </Catalysts> <Properties> <displayName>SREBP1A,1C,2 binds the FDFT1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="40" reactomeId="2426154" points="1485 184, 1517 301, 1526 356" position="1517 301" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="41" points="1470 177" /> <Input id="42" points="1646 75" /> </Inputs> <Outputs> <Output id="43" /> </Outputs> <Catalysts> <Catalyst id="42" points="1651 75, 1510 212" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the LSS promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="2426144" points="1604 197, 1621 307, 1640 357" position="1621 307" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="42" points="1658 75" /> <Input id="45" points="1591 195" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Catalysts> <Catalyst id="42" points="1661 75" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the MVD promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="49" reactomeId="2426162" points="1900 243, 1902 306, 1927 355" position="1902 306" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="42" points="1679 75" /> <Input id="50" points="1864 240" /> <Input id="55" points="2135 74" /> </Inputs> <Outputs> <Output id="51" /> </Outputs> <Catalysts> <Catalyst id="204" points="1929 305" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the HMGCR promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="52" reactomeId="2426164" points="2051 222, 2043 313, 2070 359" position="2043 313" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="53" points="2019 221" /> <Input id="42" points="1692 75" /> <Input id="55" points="2144 74" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> <Catalysts> <Catalyst id="208" points="2075 312" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the SC5DL promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="2426163" points="2502 233, 2505 363, 2524 404" position="2505 363" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="42" points="1722 75" /> <Input id="143" points="2477 241" /> <Input id="55" points="2173 74" /> <Input id="61" points="2033 70" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Catalysts> <Catalyst id="216" points="2538 347" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the CYP51A1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="62" reactomeId="2426155" points="1754 227, 1756 288, 1777 368" position="1756 288" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="42" points="1670 75" /> <Input id="63" points="1714 227" /> <Input id="55" points="2123 70" /> <Input id="61" points="1981 76" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Catalysts> <Catalyst id="226" points="1787 307" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the DHCR7 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="2426161" points="2765 170, 2767 310, 2769 371" position="2767 310" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="66" points="2718 183" /> <Input id="42" points="1741 67" /> <Input id="55" points="2179 64" /> <Input id="61" points="2033 64" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Catalysts> <Catalyst id="216" points="2607 329" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the GGPS1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="2426152" points="2663 251, 2663 339, 2665 370" position="2663 339" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="42" points="1726 75" /> <Input id="69" points="2618 245" /> <Input id="55" points="2179 69" /> <Input id="61" points="2033 68" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Catalysts> <Catalyst id="216" points="2607 335" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the IDI1 promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="71" reactomeId="2426157" points="2360 240, 2363 303, 2367 412" position="2363 303" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="72" points="2313 243" /> <Input id="42" points="1710 75" /> <Input id="55" points="2163 74" /> <Input id="61" points="2025 76" /> </Inputs> <Outputs> <Output id="73" /> </Outputs> <Catalysts> <Catalyst id="216" points="2538 328" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the MVK promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="76" reactomeId="2426156" points="2192 229, 2221 321, 2222 354" position="2221 321" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="77" points="2156 228" /> <Input id="42" points="1701 75" /> <Input id="55" points="2153 74" /> <Input id="61" points="2014 76" /> </Inputs> <Outputs> <Output id="78" /> </Outputs> <Catalysts> <Catalyst id="216" points="2538 331" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the PMVK promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="2426151" points="1373 167, 1378 297, 1407 358" position="1378 297" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="13" points="653 76" /> <Input id="42" points="1631 75" /> <Input id="80" points="1356 175" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Catalysts> <Catalyst id="233" points="1398 294" /> </Catalysts> <Properties> <displayName>SREBP1A,2 binds the SQLE promoter</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="82" reactomeId="1655826" points="1864 240, 1872 625, 1864 901" position="1872 625" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="50" /> </Inputs> <Outputs> <Output id="83" /> </Outputs> <Inhibitors> <Inhibitor id="135" points="1924 590" /> </Inhibitors> <Activators> <Activator id="51" points="1931 401" /> <Activator id="84" points="1912 623" /> </Activators> <Properties> <displayName>Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="86" reactomeId="1655827" points="1714 227, 1735 564, 1755 900" position="1735 564" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="63" /> </Inputs> <Outputs> <Output id="87" /> </Outputs> <Activators> <Activator id="64" points="1777 427" /> </Activators> <Properties> <displayName>Expression of 7-Dehydrocholesterol Reductase (DHCR7)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="88" reactomeId="1655845" points="132 103, 103 564, 79 794" position="103 564" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="7" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> <Activators> <Activator id="8" points="154 394" /> </Activators> <Properties> <displayName>Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="90" reactomeId="1655830" points="259 158, 204 569, 194 797" position="204 569" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="10" /> </Inputs> <Outputs> <Output id="91" /> </Outputs> <Activators> <Activator id="11" points="262 459" /> </Activators> <Properties> <displayName>Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="92" reactomeId="1655836" points="1591 195, 1597 565, 1611 777" position="1597 565" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="45" /> </Inputs> <Outputs> <Output id="93" /> </Outputs> <Activators> <Activator id="46" points="1642 400" /> </Activators> <Properties> <displayName>Expression of Diphosphomevalonate Decarboxylase (MVD)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="96" reactomeId="1655824" points="875 354, 881 670, 888 796" position="881 670" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="97" /> </Outputs> <Activators> <Activator id="31" points="926 611" /> </Activators> <Properties> <displayName>Expression of Farnesyl Diphosphate Synthase (FDPS)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="98" reactomeId="1655850" points="743 383, 732 675, 729 907" position="732 675" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="36" /> </Inputs> <Outputs> <Output id="99" /> </Outputs> <Activators> <Activator id="37" points="780 576" /> <Activator id="100" points="762 669" /> </Activators> <Properties> <displayName>Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="103" reactomeId="1655843" points="607 323, 639 608, 653 791" position="639 608" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="104" /> </Outputs> <Activators> <Activator id="23" points="671 536" /> </Activators> <Properties> <displayName>Expression of Fatty Acid Synthase (FASN)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="105" reactomeId="1655832" points="2718 183, 2725 572, 2725 900" position="2725 572" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="106" /> </Outputs> <Activators> <Activator id="67" points="2764 429" /> </Activators> <Properties> <displayName>Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="107" reactomeId="1655837" points="393 256, 389 304, 312 567, 241 892" position="312 567" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="18" /> </Inputs> <Outputs> <Output id="108" /> </Outputs> <Activators> <Activator id="19" points="379 489" /> </Activators> <Properties> <displayName>Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="110" reactomeId="1655848" points="1126 313, 1126 666, 1126 793" position="1126 666" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="33" /> </Inputs> <Outputs> <Output id="111" /> </Outputs> <Activators> <Activator id="34" points="1173 472" /> <Activator id="112" points="1157 654" /> </Activators> <Properties> <displayName>Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="113" reactomeId="1655823" points="2618 245, 2611 570, 2605 932" position="2611 570" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="69" /> </Inputs> <Outputs> <Output id="114" /> </Outputs> <Activators> <Activator id="70" points="2658 431" /> </Activators> <Properties> <displayName>Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="1655847" points="2477 241, 2476 557, 2464 932" position="2476 557" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="143" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> <Activators> <Activator id="58" points="2523 465" /> </Activators> <Properties> <displayName>Expression of Lanosterol Demethylase (CYP51A1)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="119" reactomeId="1655828" points="1470 177, 1480 568, 1493 900" position="1480 568" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="41" /> </Inputs> <Outputs> <Output id="120" /> </Outputs> <Activators> <Activator id="43" points="1524 399" /> </Activators> <Properties> <displayName>Expression of Lanosterol Synthase (LSS)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="121" reactomeId="1655852" points="2019 221, 2020 502, 2022 901" position="2020 502" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="122" /> </Outputs> <Activators> <Activator id="54" points="2071 403" /> </Activators> <Properties> <displayName>Expression of Lathosterol Oxidase (SC5D, SC5DL)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="123" reactomeId="1655846" points="2313 243, 2318 509, 2328 787" position="2318 509" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="72" /> </Inputs> <Outputs> <Output id="124" /> </Outputs> <Activators> <Activator id="73" points="2350 468" /> </Activators> <Properties> <displayName>Expression of Mevalonate Kinase (MVK)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="125" reactomeId="1655839" points="2156 228, 2174 502, 2186 789" position="2174 502" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="77" /> </Inputs> <Outputs> <Output id="126" /> </Outputs> <Activators> <Activator id="78" points="2213 409" /> </Activators> <Properties> <displayName>Expression of Phosphomevalonate Kinase (PMVK)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="127" reactomeId="1655844" points="1356 175, 1371 574, 1373 899" position="1371 574" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="80" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Activators> <Activator id="81" points="1412 403" /> </Activators> <Properties> <displayName>Expression of Squalene Monooxygenase (SQLE)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="131" reactomeId="1655833" points="1238 241, 1246 575, 1255 901" position="1246 575" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="15" /> </Inputs> <Outputs> <Output id="132" /> </Outputs> <Activators> <Activator id="16" points="1288 463" /> </Activators> <Properties> <displayName>Expression of TM7SF2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="133" reactomeId="1655835" points="1009 376, 1004 664, 1004 904" position="1004 664" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="27" /> </Inputs> <Outputs> <Output id="134" /> </Outputs> <Activators> <Activator id="28" points="1053 564" /> </Activators> <Properties> <displayName>Expression of ELOVL6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="138" reactomeId="6800052" points="522 361, 510 423, 534 467" position="510 423" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="139" points="498 360" /> <Input id="6" points="288 79, 496 266" /> </Inputs> <Outputs> <Output id="140" /> </Outputs> <Catalysts> <Catalyst id="185" points="537 423" /> </Catalysts> <Properties> <displayName>SREBP1A,1C binds the SCD gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="141" reactomeId="1655849" points="498 360, 489 577, 482 906" position="489 577" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="139" /> </Inputs> <Outputs> <Output id="142" /> </Outputs> <Activators> <Activator id="140" points="532 511" /> </Activators> <Properties> <displayName>Expression of Acyl-CoA Desaturase (Stearoyl CoA Desaturase, SCD)</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Activation of gene expression by SREBF (SREBP) (2426207)
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