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Details on Person SOS mediated nucleotide exchange of RAS (SHC)

Class:Id	Reaction:2424477
_displayName	SOS mediated nucleotide exchange of RAS (SHC)
_doRelease	TRUE
_timestamp	2013-02-28 10:56:43
authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
catalystActivity	[CatalystActivity:2424479] guanyl-nucleotide exchange factor activity of p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2424489] Garapati, P V, 2012-07-23
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
input	[SimpleEntity:29438] GTP [cytosol] [Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:187761] The structural basis of the activation of Ras by Sos
modified	[InstanceEdit:2428958] Garapati, P V, 2012-08-09 [InstanceEdit:2730898] Garapati, P V, 2012-12-05 [InstanceEdit:2871845] Garapati, P V, 2012-12-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS mediated nucleotide exchange of RAS (SHC)
output	[SimpleEntity:29420] GDP [cytosol] [Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:2396599] Recruitment of GRB2:SOS to p-5Y-LAT [Homo sapiens] [Reaction:2730844] Interaction of GRB2:SOS complex with p-SHC1 [Homo sapiens] [Reaction:2395801] Phosphorylation of LAT by p-SYK [Homo sapiens]
releaseDate	2012-09-18
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2464829] R-HSA-2424477.2
summation	[Summation:2424334] GRB2-bound SOS promotes the formation of active GTP-bound RA...
(hasEvent)	[Pathway:2424491] DAP12 signaling [Homo sapiens] [Pathway:2871796] FCERI mediated MAPK activation [Homo sapiens]
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No pathways have been reviewed or authored by SOS mediated nucleotide exchange of RAS (SHC) (2424477)