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Details on Person VAV2 and VAV3 are expressed in human NK cells and play a cen...
| Class:Id | Summation:2424316 |
|---|---|
| _displayName | VAV2 and VAV3 are expressed in human NK cells and play a cen... |
| _timestamp | 2012-12-03 15:34:28 |
| created | [InstanceEdit:2424330] Garapati, P V, 2012-07-23 |
| literatureReference | [LiteratureReference:2424362] The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity [LiteratureReference:2424401] Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells [LiteratureReference:2424347] Btk is a positive regulator in the TREM-1/DAP12 signaling pathway |
| modified | [InstanceEdit:2426120] Garapati, P V, 2012-07-27 [InstanceEdit:2426436] Garapati, P V, 2012-08-02 [InstanceEdit:2684975] Garapati, P V, 2012-12-03 |
| text | VAV2 and VAV3 are expressed in human NK cells and play a central role in NK cell-mediated cytotoxicity. They are required for DAP12-mediated signaling; their loss profoundly impairs DAP12-induced cytotoxicity (Billadeau et al. 2000, Cella et al. 2004). Phosphorylated SLP-76 tyrosines Y113 and Y128 provide binding sites for the SH2 domains of VAV. The binding of VAV to these phosphotyrosine residues may link SLP-76 to the Jun amino-terminal kinase (JNK) pathway and the actin cytoskeleton. Y145 has been implicated in the binding of SLP-76 to the Tec family kinase BTK (Kettner et al. 2003). BTK is required for secretion of pro-inflammatory cytokines, phosphorylation of ERK1/2 and PLCgamma and Ca2+ mobilization (Ormsby et al. 2011). |
| (summation) | [Reaction:2424481] Recruitment of VAV and BTK to p-SLP-76 [Homo sapiens] |
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No pathways have been reviewed or authored by VAV2 and VAV3 are expressed in human NK cells and play a cen... (2424316)
