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Details on Person LDLR transports extracellular CR:atREs to cytosol

Class:Id	Reaction:2424254
_displayName	LDLR transports extracellular CR:atREs to cytosol
_doRelease	TRUE
_timestamp	2026-02-18 19:17:44
authored	[InstanceEdit:2424261] Jassal, B, 2012-07-23
catalystActivity	[CatalystActivity:2424257] low-density lipoprotein particle receptor activity of LDLR [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:17941] early endosome
created	[InstanceEdit:2424261] Jassal, B, 2012-07-23
edited	[InstanceEdit:2424261] Jassal, B, 2012-07-23
inferredFrom	[Reaction:2425403] Extracellular CR:atREs are transported to cytosol by Ldlr [Mus musculus]
input	[Complex:2569093] CR:atREs [extracellular region] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2425406] Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E
modified	[InstanceEdit:2424279] Jassal, B, 2012-07-23 [InstanceEdit:2425431] Jassal, B, 2012-07-25 [InstanceEdit:2429684] Jassal, B, 2012-08-09 [InstanceEdit:2473461] Jassal, Bijay, 2012-09-24 [InstanceEdit:2534412] Jassal, Bijay, 2012-10-26 [InstanceEdit:2550421] Jassal, Bijay, 2012-11-02 [InstanceEdit:2586566] Jassal, B, 2012-11-15 [InstanceEdit:2586575] Jassal, Bijay, 2012-11-15 [InstanceEdit:2864105] Jassal, Bijay, 2012-12-19 [InstanceEdit:3006583] Jassal, Bijay, 2013-01-31 [InstanceEdit:3006617] Jassal, B, 2013-01-31 [InstanceEdit:5153513] Jassal, B, 2013-11-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9982628] D'Eustachio, Peter, 2026-02-18
name	LDLR transports extracellular CR:atREs to cytosol Circulating chylomicron remnants can be directly cleared by the LDL receptor
output	[Complex:2429667] CR:atREs [early endosome] [Homo sapiens]
precedingEvent	[Reaction:2395768] LPL hydrolyses TGs from mature CMs [Homo sapiens] [BlackBoxEvent:2395784] Nascent CMs transform into mature CMs [Homo sapiens]
releaseDate	2013-03-12
reviewed	[InstanceEdit:3006584] Blaner, William S, 2013-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200697] R-HSA-2424254.3
summation	[Summation:2424271] Chylomicron remnants (CRs) are "sieved" when they arrive at ...
(hasEvent)	[Pathway:975634] Retinoid metabolism and transport [Homo sapiens]
(precedingEvent)	[Reaction:2404140] NREH hydrolyses atREs to atROL and FAs [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786736] Update Tracker - [Reaction:2424254] LDLR transports extracellular CR:atREs to cytosol - v48:[add_removeInput]
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No pathways have been reviewed or authored by LDLR transports extracellular CR:atREs to cytosol (2424254)