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Details on Person UniProt:O95453 PARN
| Class:Id | ReferenceGeneProduct:241708 |
|---|---|
| _chainChangeLog | chain:1-639 added on Fri February 6 2015 |
| _displayName | UniProt:O95453 PARN |
| _timestamp | 2024-11-03 19:57:51 |
| chain | chain:1-639 |
| checksum | 6994BE39384DF7AC |
| comment | FUNCTION 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417).CATALYTIC ACTIVITY Exonucleolytic cleavage of poly(A) to 5'-AMP.COFACTOR Divalent metal cations. Mg(2+) is the most probable.SUBUNIT Homodimer (PubMed:10801819, PubMed:16281054). Found in a mRNA decay complex with RENT1, RENT2 and RENT3B (PubMed:14527413). Interacts with KHSRP (PubMed:15175153). Interacts with CELF1/CUGBP1 (PubMed:16601207). Interacts with ZC3HAV1 in an RNA-independent manner (PubMed:21876179). Interacts with DHX36 (PubMed:14731398).INTERACTION Some nuclear fraction is nucleolar.ALTERNATIVE PRODUCTS Ubiquitous.PTM Phosphorylation by MAPKAPK2, preventing GADD45A mRNA degradation after genotoxic stress.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Non canonical splice junctions.SIMILARITY Belongs to the CAF1 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Poly(A)-specific ribonuclease PARN ecNumber: 3.1.13.4 alternativeName: Deadenylating nuclease alternativeName: Deadenylation nuclease alternativeName: Polyadenylate-specific ribonuclease |
| geneName | PARN DAN |
| identifier | O95453 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Disease variant Dyskeratosis congenita Exonuclease Hydrolase Magnesium Metal-binding Nonsense-mediated mRNA decay Nuclease Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PARN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8954600] ENSEMBL:ENSG00000140694 PARN [Homo sapiens] |
| secondaryIdentifier | PARN_HUMAN B2RCB3 B4DDG8 B4DSB0 B4DWR4 B4E1H6 |
| sequenceLength | 639 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968914] UniProt:O95453-1 PARN [Homo sapiens] [ReferenceIsoform:8968915] UniProt:O95453-2 PARN [Homo sapiens] [ReferenceIsoform:8968916] UniProt:O95453-3 PARN [Homo sapiens] [ReferenceIsoform:8968917] UniProt:O95453-4 PARN [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:430009] PARN [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9935621] PARN [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95453 PARN (241708)
