Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9BRP4 PAAF1
| Class:Id | ReferenceGeneProduct:241520 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-392 added on Sat February 7 2015;initiator methionine:1 for 241520 removed on Fri Nov 03 2023;initiator methionine: for 241520 added on Fri Nov 03 2023;initiator methionine: for 241520 removed on Fri Aug 15 2025;initiator methionine:1 for 241520 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9BRP4 PAAF1 |
| _timestamp | 2025-08-15 21:25:07 |
| chain | initiator methionine:1 chain:2-392 |
| checksum | 54ECB1DEC1841B49 |
| comment | FUNCTION Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.SUBUNIT Interacts with PSMC1, PSMC2, PSMC3, PSMC4, PSMC5 and PSMC6. Interacts with SUPT6H.SUBUNIT (Microbial infection) Interacts with HIV-1 Tat.INTERACTION Ubiquitously expressed, with highest levels in kidney, brain and testis.SIMILARITY Belongs to the WD repeat PAAF1/RPN14 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Proteasomal ATPase-associated factor 1 alternativeName: Protein G-16 alternativeName: WD repeat-containing protein 71 |
| geneName | PAAF1 WDR71 |
| identifier | Q9BRP4 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Host-virus interaction Proteasome Proteomics identification Reference proteome Repeat WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PAAF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962529] ENSEMBL:ENSG00000175575 PAAF1 [Homo sapiens] |
| secondaryIdentifier | PAAF1_HUMAN A6NDR5 B4DPB0 B7ZAS9 Q4G165 Q53HS9 Q7Z500 Q8TBU6 Q9HAB6 |
| sequenceLength | 392 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:241521] UniProt:Q9BRP4-2 PAAF1 [Homo sapiens] [ReferenceIsoform:413363] UniProt:Q9BRP4-1 PAAF1 [Homo sapiens] [ReferenceIsoform:8974814] UniProt:Q9BRP4-3 PAAF1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9907973] PAAF1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BRP4 PAAF1 (241520)
