Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q80VM9 Otop1
| Class:Id | ReferenceGeneProduct:241280 |
|---|---|
| _chainChangeLog | chain:1-600 added on Fri February 6 2015 |
| _displayName | UniProt:Q80VM9 Otop1 |
| _timestamp | 2024-08-09 19:59:54 |
| chain | chain:1-600 |
| checksum | CC10FA749803064B |
| comment | FUNCTION Proton-selective ion channel (PubMed:29371428, PubMed:31160780, PubMed:31543453, PubMed:36596786, PubMed:37798269). Biphasically modulated by acid and alkali, mediating proton influx and efflux in response to extracellular acid and base stimulation, respectively (PubMed:36596786, PubMed:37798269). Sour taste receptor, which carries inward currents in response to extracellular acidification (PubMed:29371428, PubMed:31543264, PubMed:31543453, PubMed:37053086). Sensor for ammonium chloride (NH(4)Cl) in taste receptor cells. NH(4)Cl acts by increasing the intracellular pH, thereby generating a driving force for proton entry through OTOP1 channel (PubMed:37798269). Might also participate in alkaline sensation (PubMed:37798269). Plays a role in the regulation of Ca(2+) flux in response to purigenic (ATP, ADP and UDP) stimuli, leading to increase in cytosolic Ca(2+) due to influx of extracellular calcium (PubMed:17606897, PubMed:20554841). May play this role by inhibiting P2Y purinoceptor-mediated Ca(2+) release in a Ca(2+)-dependent manner and promote an influx of Ca(2+) in response to ATP (PubMed:20554841). Through this mechanism and possibly others, plays a role in the formation and function of calcium carbonate-based structures in the vestibular system of the inner ear, called otoconia, that sense gravity and linear acceleration (PubMed:12651873, PubMed:20554841). In obesity, may attenuate adipose tissue inflammation, through the negative regulation of IFNG signaling, hence may play an adaptive role in the maintainance of metabolic homeostasis (PubMed:24379350). Following alkali activation, may also be permeable Na(+), K(+), Cs(+) and Li(+) (PubMed:37798269).CATALYTIC ACTIVITY H(+)(in) = H(+)(out)ACTIVITY REGULATION Activated by both acid and alkali, with proton influx in response to extracellular acid and proton efflux during alkali stimulation (PubMed:29371428, PubMed:36596786). Inhibited by Zn(2+); this inhibition is thought to be pH-sensitive (PubMed:29371428, PubMed:31543453, PubMed:36596786, PubMed:37798269). Currents evoked in response to mild acid (pH 6.0) stimulus may also be mildly potentiated by exposure to Zn(2+) (PubMed:37053086, PubMed:37798269). Activated by NH(4)Cl (PubMed:37798269).SUBUNIT Homodimer (By similarity). Interacts with STAT1, independently of STAT1 phosphorylation status (PubMed:24379350).SUBCELLULAR LOCATION Found in the gelatinous membrane overlying the inner ear macular epithelium (PubMed:12651873, PubMed:21236346). Also detected in the apical microvilli in inner ear supporting cells (PubMed:20554841).ALTERNATIVE PRODUCTS Expressed in thymus, heart, kidney, skin, vestibular system of the inner ear, sour taste cells, heart, uterus, dorsal root ganglion, adrenal gland, lactating mammary gland and stimulated mast cells (PubMed:12651873, PubMed:29371428). In the inner ear, expressed in the supporting cells in extrastriolar regions of the saccule and in the utricle, but not in the cochlea (PubMed:20554841). Expressed in brown adipose tissue. Expressed in epididymal white adipose tissue (eWAT), as well as in inguinal fat, in obese animals, but hardly detectable in eWAT from lean mice (PubMed:24379350). Expressed in acid-sensing taste receptor cells (PKD2L1-positive cells), but not in other types of taste cells (at protein level) (PubMed:29371428, PubMed:31543264, PubMed:31543453, PubMed:36596786).DEVELOPMENTAL STAGE In the developing ear, first detected at 13.5 dpc in the utricule. Expression in the saccule begins at 14.5 dpc (PubMed:20554841). At 16.5 dpc, present throughout the whole epithelium in the utricle and saccule. At this stage, expressed in macula nonstriolar, but not striolar regions (PubMed:12651873, PubMed:20554841). At 16.5 dpc, also found in the gelatinous membrane overlying macular epithelia (at protein level) (PubMed:12651873). At 18.5 dpc, expressed in otocyst (PubMed:12651873).INDUCTION Up-regulated in adipocytes in response to TNF, but not IFNG (PubMed:24379350). Up-regulated in epididymal white adipose tissue in animals on high-fat diet (PubMed:24379350).DOMAIN Residues involved in the gating by extracellular Zn (2+) and pH are located in the extracellular loops between transmembrane domain 5-6 and transmembrane domain 11-12.DISRUPTION PHENOTYPE Knockout mice are phenotypically normal. They show vestibular dysfunction (inability to swim) and otoconial agenesis (PubMed:20554841, PubMed:31543453). They also exhibit severely diminished cellular and gustatory nerve response to acids (PubMed:31543264, PubMed:31543453). However, they do not exhibit any difference compared to wild-type mice in behavioral aversion to solutions containing high concentrations of mineral or organic acids, possibly because of the activation of nociceptive neurons through an OTOP1-independent mechanism (PubMed:31543264, PubMed:31543453). Knockout mice show a significantly diminished aversion to NH(4)Cl compared to wild-type animals (PubMed:37798269).SIMILARITY Belongs to the otopetrin family.ONLINE INFORMATION Ear of stone - Issue 89 of December 2007 |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="17"Proton channel OTOP1 alternativeName: fullName evidence="15"Otopetrin-1 |
| geneName | Otop1 |
| identifier | Q80VM9 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Biomineralization Cell membrane Cell projection Hydrogen ion transport Ion channel Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Otop1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OTOP1_MOUSE A0A0R4J1J4 E9QMU2 Q7M735 Q8BRZ4 Q8BS22 |
| sequenceLength | 600 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:241281] UniProt:Q80VM9-2 Otop1 [Mus musculus] [ReferenceIsoform:241282] UniProt:Q80VM9-3 Otop1 [Mus musculus] [ReferenceIsoform:409625] UniProt:Q80VM9-1 Otop1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9729553] Otop1 [plasma membrane] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q80VM9 Otop1 (241280)
