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Details on Person UniProt:Q9WVG7 Osr1
| Class:Id | ReferenceGeneProduct:241237 |
|---|---|
| _chainChangeLog | chain:1-266 added on Sat February 7 2015 |
| _displayName | UniProt:Q9WVG7 Osr1 |
| _timestamp | 2026-02-20 22:58:04 |
| chain | chain:1-266 |
| checksum | CC9948ACFC90F7A5 |
| comment | FUNCTION Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.SUBCELLULAR LOCATION Expressed in the kidney along the thick ascending limb and the distal convoluted tubule (at protein level).DEVELOPMENTAL STAGE During early embryogenesis it is expressed in the intermediate mesoderm and in a dynamic pattern during limb and branchial arch development. Is expressed from the earliest stage of intermediate development. Is expressed in the dorsal atrial wall, including the developing primary atrial septum and the venous valve.INDUCTION Transcriptionally regulated by Ikzf1 and Runx2.DISRUPTION PHENOTYPE Mice die prenatally with severe heart defects including defective atrioventricular junction and venous valves. They never initiate metanephric kidney formation. Nephrogenic mesenchyme undergo massive apoptosis, which causes a disruption of nephric duct elongation and failure of metanephric induction.SIMILARITY Belongs to the Odd C2H2-type zinc-finger protein family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Protein odd-skipped-related 1 |
| geneName | Osr1 Odd1 |
| identifier | Q9WVG7 |
| isSequenceChanged | FALSE |
| keyword | Metal-binding Methylation Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Osr1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OSR1_MOUSE |
| sequenceLength | 266 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9761196] Osr1 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9WVG7 Osr1 (241237)
