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Details on Person UniProt:A1E959 ODAM
| Class:Id | ReferenceGeneProduct:240941 |
|---|---|
| _chainChangeLog | signal peptide:1-15 added on Fri February 6 2015;chain:16-279 added on Fri February 6 2015 |
| _displayName | UniProt:A1E959 ODAM |
| _timestamp | 2024-11-03 19:52:58 |
| chain | signal peptide:1-15 chain:16-279 |
| checksum | DE0E42076B572318 |
| comment | FUNCTION Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.SUBUNIT Interacts (via C-terminus) with ARHGEF5.INTERACTION Expressed in the junctional epithelium of healthy teeth. In periodontitis, absent in the pocket epithelium of the diseased periodontium but is detected in the gingival crevicular fluid.PTM O-glycosylated.MISCELLANEOUS ODAM protein is the unique constituent of calcifying epithelial odontogenic tumors (CEOTs), also known as Pindborg tumors. CEOTs are benign but locally aggressive pathologic entities arising mainly in the mandible and commonly associated with an unerupted or embedded tooth. They are characterized by the presence of squamous-cell proliferation, calcification, and, notably, amyloid deposits.SIMILARITY Belongs to the ODAM family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Odontogenic ameloblast-associated protein alternativeName: Apin |
| geneName | ODAM APIN |
| identifier | A1E959 |
| isSequenceChanged | FALSE |
| keyword | Biomineralization Cytoplasm Glycoprotein Nucleus Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ODAM |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003691] ENSEMBL:ENSG00000109205 ODAM [Homo sapiens] |
| secondaryIdentifier | ODAM_HUMAN Q8WWE5 Q9NWZ9 |
| sequenceLength | 279 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:977149] ODAM [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A1E959 ODAM (240941)
