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Details on Person SeO3(2-) is reduced to H2Se by TXNRD1

Class:Id	Reaction:2408558
_displayName	SeO3(2-) is reduced to H2Se by TXNRD1
_doRelease	TRUE
_timestamp	2015-11-20 15:07:42
authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359081] selenite reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
inferredFrom	[Reaction:2408527] SeO3(2-) is reduced to H2Se by TXNRD1 [Bos taurus]
input	[SimpleEntity:5357720] SeO3(2-) [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5359344] Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases [LiteratureReference:5359340] Selenite is a substrate for calf thymus thioredoxin reductase and thioredoxin and elicits a large non-stoichiometric oxidation of NADPH in the presence of oxygen
modified	[InstanceEdit:5333616] Williams, MG, 2014-02-19 [InstanceEdit:5357739] Williams, MG, 2014-03-26 [InstanceEdit:5359131] Williams, MG, 2014-04-08 [InstanceEdit:5359396] Williams, MG, 2014-04-09 [InstanceEdit:5422928] Williams, MG, 2014-05-06 [InstanceEdit:5422935] Williams, MG, 2014-05-06 [InstanceEdit:6793107] D'Eustachio, Peter, 2015-08-30 [InstanceEdit:6793354] D'Eustachio, Peter, 2015-09-01 [InstanceEdit:6804181] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:6804182] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SeO3(2-) is reduced to H2Se by TXNRD1
output	[SimpleEntity:5357660] selanide [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:2408548] PAPSe is reduced to SeO3(2-) by PAPSe reductase [Homo sapiens] [Reaction:2408540] APSe is phosphorylated to PAPSe by PAPSS1,2 [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812325] R-HSA-2408558.2
summation	[Summation:5422895] Thioredoxin reductase 1 (TXNRD1) homodimer (Sun et al. 1999)...
(hasEvent)	[Pathway:2408550] Metabolism of ingested H2SeO4 and H2SeO3 into H2Se [Homo sapiens]
(precedingEvent)	[Reaction:2408536] H2Se is methylated to MeSeH by H2Se methyltransferase [Homo sapiens] [Reaction:8959510] SEPHS2 phosphorylates H2Se to form SELP [Homo sapiens]
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