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Details on Person H2Se is methylated to MeSeH by H2Se methyltransferase

Class:Id	Reaction:2408536
_displayName	H2Se is methylated to MeSeH by H2Se methyltransferase
_doRelease	TRUE
_timestamp	2015-11-20 15:07:30
authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359071] hydrogen selenide methyltransferase activity of HSeMT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
inferredFrom	[Reaction:2408511] H2Se is methylated to MeSeH by H2Se methyltransferase [Rattus norvegicus]
input	[SimpleEntity:5357660] selanide [cytosol] [SimpleEntity:71284] AdoMet [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5359231] Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium [LiteratureReference:5359234] Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems
modified	[InstanceEdit:5333616] Williams, MG, 2014-02-19 [InstanceEdit:5359402] Williams, MG, 2014-04-09 [InstanceEdit:5422928] Williams, MG, 2014-05-06 [InstanceEdit:5422935] Williams, MG, 2014-05-06 [InstanceEdit:6793107] D'Eustachio, Peter, 2015-08-30 [InstanceEdit:6793354] D'Eustachio, Peter, 2015-09-01 [InstanceEdit:6804181] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:6804182] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:6804184] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	H2Se is methylated to MeSeH by H2Se methyltransferase
output	[SimpleEntity:5357669] MeSeH [cytosol] [SimpleEntity:71285] AdoHcy [cytosol]
precedingEvent	[Reaction:2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer [Homo sapiens] [Reaction:2408543] SeCysta is hydrolysed to Sec by PXLP-K212-CTH [Homo sapiens] [Reaction:2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase [Homo sapiens] [Reaction:2408537] Excess SeMet is cleaved into MeSeH by PXLP-K212-CTH [Homo sapiens] [Reaction:2408539] MeSec is hydrolysed to MeSeH by PXLP-K212-CTH [Homo sapiens] [Reaction:2408536] H2Se is methylated to MeSeH by H2Se methyltransferase [Homo sapiens] [Reaction:5263614] MeSeOH is reduced to MeSeH by TXNRD1 [Homo sapiens] [BlackBoxEvent:5333609] MeSebGalNac is hydrolysed to MeSeH and bGalNac [Homo sapiens] [Reaction:2408558] SeO3(2-) is reduced to H2Se by TXNRD1 [Homo sapiens] [Reaction:2408548] PAPSe is reduced to SeO3(2-) by PAPSe reductase [Homo sapiens] [Reaction:2408500] GSSeH condenses with GSH to form H2Se and GSSG [Homo sapiens] [Reaction:2408542] GSSeSG is reduced to GSSeH and GSH by GSR [Homo sapiens] [BlackBoxEvent:5333608] GSSebGalNac is reduced and methylated to MeSebGalNac [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812307] R-HSA-2408536.2
summation	[Summation:5422920] A yet to be identified enzyme with hydrogen selenide methylt...
(hasEvent)	[Pathway:2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se [Homo sapiens]
(precedingEvent)	[Reaction:2408530] MeSeH is hydrolysed to H2Se by methylselenol demethylase [Homo sapiens] [Reaction:2408541] MeSeH is methylated to Me2Se by MeSeH methyltransferase [Homo sapiens]
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