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Details on Person Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome

Class:Id	Reaction:2408529
_displayName	Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome
_doRelease	TRUE
_timestamp	2025-02-25 22:17:42
authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:9930626] selenocysteine insertion sequence binding activity of SECISBP2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9930617] selenocysteine insertion sequence binding activity of SECISBP2 [cytosol] Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
inferredFrom	[Reaction:2408535] Sec-tRNA(Sec):Eefsec:GTP binds to Rpl30 [Rattus norvegicus]
input	[Complex:5359036] Sec-tRNA(Sec):EEFSEC:GTP [cytosol] [Homo sapiens] [Complex:72505] 80S:Met-tRNAi:mRNA [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5357715] SECISBP2 [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9930750] D'Eustachio, Peter, 2024-12-05
isChimeric	FALSE
literatureReference	[LiteratureReference:5359334] Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes
modified	[InstanceEdit:5333616] Williams, MG, 2014-02-19 [InstanceEdit:5357739] Williams, MG, 2014-03-26 [InstanceEdit:5359120] Williams, MG, 2014-04-08 [InstanceEdit:5359394] Williams, MG, 2014-04-09 [InstanceEdit:5422928] Williams, MG, 2014-05-06 [InstanceEdit:5422935] Williams, MG, 2014-05-06 [InstanceEdit:6793107] D'Eustachio, Peter, 2015-08-30 [InstanceEdit:6793354] D'Eustachio, Peter, 2015-09-01 [InstanceEdit:6804181] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:6804182] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04 [InstanceEdit:9930749] D'Eustachio, Peter, 2024-12-06 [InstanceEdit:9939374] D'Eustachio, Peter, 2025-02-25
name	Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome
output	[Complex:5359044] 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] [Homo sapiens]
precedingEvent	[Reaction:2408509] Sec-tRNA(Sec) binds to EEFSEC:GTP [Homo sapiens] [Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30 [InstanceEdit:9939375] Hill, David P, 2025-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812302] R-HSA-2408529.3
structureModified	[InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
summation	[Summation:5359358] The complex consisting of selenocysteinyl (Sec) transfer RNA...
(hasEvent)	[Pathway:2408557] Selenocysteine synthesis [Homo sapiens]
(precedingEvent)	[Reaction:5333615] 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939623] Update Tracker - [Reaction:2408529] Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome - v92:[removeCatalystActivity]
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No pathways have been reviewed or authored by Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (2408529)