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Details on Person Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK

Class:Id	Reaction:2408507
_displayName	Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK
_doRelease	TRUE
_timestamp	2024-12-04 22:40:00
authored	[InstanceEdit:5422928] Williams, MG, 2014-05-06
catalystActivity	[CatalystActivity:5359089] seryl-selenocysteinyl-tRNA kinase activity of PSTK:Mg2+ [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2408534] Williams, MG, 2012-07-17
crossReference	[DatabaseIdentifier:9930608] RHEA:25038
edited	[InstanceEdit:6793109] D'Eustachio, Peter, 2015-08-29
inferredFrom	[Reaction:2408505] Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by Pstk [Mus musculus]
input	[GenomeEncodedEntity:5357730] Ser-tRNA(Sec) [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:5359299] Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase
modified	[InstanceEdit:5357739] Williams, MG, 2014-03-26 [InstanceEdit:5359117] Williams, MG, 2014-04-08 [InstanceEdit:5359395] Williams, MG, 2014-04-09 [InstanceEdit:5422928] Williams, MG, 2014-05-06 [InstanceEdit:5422935] Williams, MG, 2014-05-06 [InstanceEdit:6793107] D'Eustachio, Peter, 2015-08-30 [InstanceEdit:6793354] D'Eustachio, Peter, 2015-09-01 [InstanceEdit:6804181] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:6804182] D'Eustachio, Peter, 2015-10-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9930615] D'Eustachio, Peter, 2024-12-04
name	Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK ATP + L-seryl-tRNA(Sec) => ADP + O-phospho-L-seryl-tRNA(Sec)
output	[GenomeEncodedEntity:5357712] Sep-tRNA(Sec) [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:2408526] tRNA(Sec) is serylated to Ser-tRNA(Sec) by SARS dimer [Homo sapiens] [Reaction:5333615] 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC [Homo sapiens]
releaseDate	2015-12-15
releaseStatus	NEW
reviewed	[InstanceEdit:6793106] Rush, MG, 2015-08-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6812286] R-HSA-2408507.3
summation	[Summation:5359324] L-seryl-tRNA(Sec) kinase (PSTK) phosphorylates the serylated...
(hasEvent)	[Pathway:2408557] Selenocysteine synthesis [Homo sapiens]
(precedingEvent)	[Reaction:2408555] Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer [Homo sapiens]
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No pathways have been reviewed or authored by Ser-tRNA(Sec) is phosphorylated to Sep-tRNA(Sec) by PSTK (2408507)