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Details on Person Orlic-Milacic, M, 2012-07-16

Class:IdInstanceEdit:2404247
_displayNameOrlic-Milacic, M, 2012-07-16
_timestamp2012-07-16 19:25:12
author[Person:1169272] Orlic-Milacic, Marija
dateTime2012-07-16 23:25:12
(modified)[PathwayDiagram:1273430] Diagram of PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by AKT1 E17K in Cancer, and PTEN Loss of Function in Cancer
[Reaction:2219536] AKT1 E17K mutant binds PIP2 [Homo sapiens]
[Reaction:2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 [Homo sapiens]
[Reaction:2243938] AKT1 E17K mutant is phosphorylated by TORC2 complex [Homo sapiens]
[Reaction:2243942] PDPK1 phosphorylates AKT1 E17K mutant [Homo sapiens]
[FailedReaction:2317387] PTEN cancer mutants do not dephosphorylate PIP3 [Homo sapiens]
[Reaction:2399941] AKT1 E17K mutant phosphorylates BAD [Homo sapiens]
[Reaction:2399966] AKT1 E17K mutant phosphorylates GSK3 [Homo sapiens]
[Reaction:2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 [Homo sapiens]
[Reaction:2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) [Homo sapiens]
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No pathways have been reviewed or authored by Orlic-Milacic, M, 2012-07-16 (2404247)