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Details on Person A REH hydrolyses atREs to atROL and FAs

Class:IdBlackBoxEvent:2404133
_displayNameA REH hydrolyses atREs to atROL and FAs
_doReleaseTRUE
_timestamp2026-02-18 21:20:52
authored[InstanceEdit:2404143] Jassal, B, 2012-07-16
catalystActivity[CatalystActivity:2453682] retinyl-palmitate esterase activity of REH [cytosol]
compartment[Compartment:70101] cytosol
[Compartment:13977] lipid droplet
created[InstanceEdit:2404143] Jassal, B, 2012-07-16
crossReference[DatabaseIdentifier:9982477] RHEA:38556
edited[InstanceEdit:2404143] Jassal, B, 2012-07-16
input[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:9982476] atRE [lipid droplet]
internalReviewed[InstanceEdit:9982705] D'Eustachio, Peter, 2026-02-18
isChimericFALSE
literatureReference[LiteratureReference:2453681] Hepatic metabolism of retinoids and disease associations
[LiteratureReference:2453697] Retinyl ester hydrolases and their roles in vitamin A homeostasis
[LiteratureReference:2453710] Expression of carboxylesterase and lipase genes in rat liver cell-types
modified[InstanceEdit:2453711] Jassal, B, 2012-08-14
[InstanceEdit:2473461] Jassal, Bijay, 2012-09-24
[InstanceEdit:2473613] Jassal, Bijay, 2012-09-24
[InstanceEdit:2550421] Jassal, Bijay, 2012-11-02
[InstanceEdit:2586575] Jassal, Bijay, 2012-11-15
[InstanceEdit:2864105] Jassal, Bijay, 2012-12-19
[InstanceEdit:3006583] Jassal, Bijay, 2013-01-31
[InstanceEdit:3006617] Jassal, B, 2013-01-31
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9982480] D'Eustachio, Peter, 2026-02-17
[InstanceEdit:9982704] D'Eustachio, Peter, 2026-02-18
[InstanceEdit:9982753] D'Eustachio, Peter, 2026-02-18
nameA REH hydrolyses atREs to atROL and FAs
an all-trans-retinyl ester + H2O => all-trans-retinol + a fatty acid + H(+)
output[SimpleEntity:2473616] atROL [cytosol]
[SimpleEntity:9982478] RCOO- [lipid droplet]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2013-03-12
reviewed[InstanceEdit:3006584] Blaner, William S, 2013-01-31
[InstanceEdit:9982754] D'Eustachio, Peter, 2026-02-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200357] R-HSA-2404133.3
structureModified[InstanceEdit:9982480] D'Eustachio, Peter, 2026-02-17
summation[Summation:2453694] Retinyl esters (REs) are stored in lipid droplets (LDs) in h...
(hasEvent)[Pathway:975634] Retinoid metabolism and transport [Homo sapiens]
(precedingEvent)[BlackBoxEvent:2404139] HSC cytosolic atROL translocates to extracellular region [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984564] Update Tracker - [BlackBoxEvent:2404133] A REH hydrolyses atREs to atROL and FAs - v96:[add_removeInput, add_removeOutput, modifyText]
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