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Details on Person UniProt:Q9UHY1 NRBP1
| Class:Id | ReferenceGeneProduct:240195 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-535 added on Fri February 6 2015;initiator methionine:1 for 240195 removed on Fri Nov 03 2023;initiator methionine: for 240195 added on Fri Nov 03 2023;initiator methionine: for 240195 removed on Fri Aug 15 2025;initiator methionine:1 for 240195 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9UHY1 NRBP1 |
| _timestamp | 2025-08-15 22:10:12 |
| chain | initiator methionine:1 chain:2-535 |
| checksum | 398078661547EDD0 |
| comment | FUNCTION Required for embryonic development (By similarity). Plays a role in intestinal epithelial cell fate and proliferation, thereby involved in the architectural development of the intestine potentially via the regulation of Wnt-responsive genes (By similarity). May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (PubMed:11956649). Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication (PubMed:15084397).SUBUNIT Homodimer (By similarity). Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1 (By similarity). Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm (By similarity). Interacts with ELOC/TCEB1, ELOB/TCEB2, TSC22D2 and TSC22D4 (PubMed:22510880). Interacts with the Elongin BC E3 ubiquitin ligase complex via its interaction with ELOB/TCEB2 and ELOC/TCEB1 (PubMed:22510880). Interacts with SALL4 (PubMed:22510880).INTERACTION Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.TISSUE SPECIFICITY Ubiquitously expressed in all tissues examined with high levels in the testis.DOMAIN The protein kinase domain is predicted to be catalytically inactive.MISCELLANEOUS May act as a tumor suppressor to decrease tumor incidence and improve survival (PubMed:22510880). Expression levels have also been found to be reduced in a range of tumor types, such as leukemia, lymphoma, colorectal, breast, brain, esophageal, renal cell, prostate and lung (PubMed:22510880).SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.CAUTION Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Nuclear receptor-binding protein |
| geneName | NRBP1 BCON3 NRBP |
| identifier | Q9UHY1 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell projection Cytoplasm Membrane Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NRBP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998478] ENSEMBL:ENSG00000115216 NRBP1 [Homo sapiens] |
| secondaryIdentifier | NRBP_HUMAN B3KV40 D6W558 Q53FZ5 Q96SU3 |
| sequenceLength | 535 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:376332] NRBP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9921256] NRBP1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UHY1 NRBP1 (240195)
