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Details on Person UniProt:Q96F24-2 NRBF2
| Class:Id | ReferenceIsoform:240189 |
|---|---|
| _chainChangeLog | chain:1-287 added on Sat February 7 2015 |
| _displayName | UniProt:Q96F24-2 NRBF2 |
| _timestamp | 2025-02-21 19:20:25 |
| chain | chain:1-287 |
| checksum | 91EC0407F5108806 |
| comment | FUNCTION May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).FUNCTION Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).SUBUNIT Interacts with PPARA, PPARD and PPARG. Interacts with RARA, RARG and RXRA in the presence of bound ligand (PubMed:15610520). Interacts with SCOC (PubMed:22354037). Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (PubMed:24785657).INTERACTION Detected in keratinocytes, liver and placenta (PubMed:15610520). Expressed in a subset of cells in pediatric medulloblastoma (PubMed:18619852). |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Nuclear receptor-binding factor 2 shortName: NRBF-2 alternativeName: Comodulator of PPAR and RXR |
| geneName | NRBF2 COPR |
| identifier | Q96F24 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Autophagy Coiled coil Cytoplasm Cytoplasmic vesicle Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NRBF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999645] ENSEMBL:ENSG00000148572 NRBF2 [Homo sapiens] |
| secondaryIdentifier | NRBF2_HUMAN A6PW36 B4DWS0 Q86UR2 Q96NP6 Q9H0S9 Q9H2I2 |
| sequenceLength | 287 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96F24-2 |
| (referenceEntity) | [EntityWithAccessionedSequence:3196154] NRBF2-2 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96F24-2 NRBF2 (240189)
