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Details on Person UniProt:O95436 SLC34A2

Class:Id	ReferenceGeneProduct:240019
_chainChangeLog	chain:1-690 added on Sat February 7 2015
_displayName	UniProt:O95436 SLC34A2
_timestamp	2024-11-03 19:42:16
chain	chain:1-690
checksum	3BDB1920CA92C035
comment	FUNCTION Involved in actively transporting phosphate into cells via Na(+) cotransport.CATALYTIC ACTIVITY 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)CATALYTIC ACTIVITY 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 6.6.INTERACTION Localized at the brush border membranes of enterocytes.ALTERNATIVE PRODUCTS Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.INDUCTION Down-regulated by EGF.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity.SIMILARITY Belongs to the SLC34A transporter family.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Sodium-dependent phosphate transport protein 2B shortName: Sodium-phosphate transport protein 2B alternativeName: Na(+)-dependent phosphate cotransporter 2B alternativeName: NaPi3b alternativeName: Sodium/phosphate cotransporter 2B shortName: Na(+)/Pi cotransporter 2B shortName: NaPi-2b alternativeName: Solute carrier family 34 member 2
geneName	SLC34A2
identifier	O95436
isSequenceChanged	FALSE
keyword	Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Ion transport Membrane Proteomics identification Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	SLC34A2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8989671] ENSEMBL:ENSG00000157765 SLC34A2 [Homo sapiens]
secondaryIdentifier	NPT2B_HUMAN A5PL17 Q8N2K2 Q8WYA9 Q9P0V7
sequenceLength	690
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:240020] UniProt:O95436-2 SLC34A2 [Homo sapiens] [ReferenceIsoform:402146] UniProt:O95436-1 SLC34A2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:427586] SLC34A2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5651665] SLC34A2 K304* [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5651668] SLC34A2 Q76* [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5651681] SLC34A2 N38Tfs8 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5651703] SLC34A2 G106R [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5687587] SLC34A2 Q486 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5687603] SLC34A2 V448* [plasma membrane] [Homo sapiens]
(referenceSequence)	[ReplacedResidue:5651666] glycine 106 replaced with L-arginine [FragmentReplacedModification:5651671] Replacement of residues 38 to 44 by TITLRHL [NonsenseMutation:5651684] Nonsense mutation at L-lysine 304 [NonsenseMutation:5651688] Nonsense mutation at L-glutamine 76 [NonsenseMutation:5687592] Nonsense mutation at L-valine 448 [NonsenseMutation:5687617] Nonsense mutation at L-glutamine 486
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No pathways have been reviewed or authored by UniProt:O95436 SLC34A2 (240019)